Effect of pentane-1,5-diol and propane-1,2-diol on percutaneous absorption of terbinafine
Journal article, 2009
The aim of this study was to compare pentane-1,5-diol and propane-1,2-diol used as absorption enhancers for cutaneously administered terbinafine. Fresh human skin samples were placed in a continuous flow diffusion cell with a gel containing terbinafine on top of the skin. Receptor fluid samples were analysed using high - performance liquid chromatography. The quantity of gel remaining on the skin surface after completion of each test was weighed and the amount of drug in the skin was analysed. Addition of pentane-1,5-diol or propane-1,2-diol to the gel increased the percutaneous absorption of the drug. The most efficient absorption enhancer in this comparison was 5% pentane-1,5-diol.
Cutaneous
Vehicles/pharmacology
Naphthalenes/administration & dosage/*pharmacokinetics
Chromatography
Humans
High Pressure Liquid
Propylene Glycol/*pharmacology
Glycols/*pharmacology
Gels
Skin Absorption/*drug effects
Administration
Antifungal Agents/administration & dosage/*pharmacokinetics
Author
Hanne Evenbratt
University of Gothenburg
Jan Faergemann
University of Gothenburg
Acta Dermato-Venereologica
0001-5555 (ISSN) 1651-2057 (eISSN)
Vol. 89 2 126-9Subject Categories
Dermatology and Venereal Diseases
DOI
10.2340/00015555-0594