Effect of pentane-1,5-diol and propane-1,2-diol on percutaneous absorption of terbinafine
Artikel i vetenskaplig tidskrift, 2009

The aim of this study was to compare pentane-1,5-diol and propane-1,2-diol used as absorption enhancers for cutaneously administered terbinafine. Fresh human skin samples were placed in a continuous flow diffusion cell with a gel containing terbinafine on top of the skin. Receptor fluid samples were analysed using high - performance liquid chromatography. The quantity of gel remaining on the skin surface after completion of each test was weighed and the amount of drug in the skin was analysed. Addition of pentane-1,5-diol or propane-1,2-diol to the gel increased the percutaneous absorption of the drug. The most efficient absorption enhancer in this comparison was 5% pentane-1,5-diol.

Cutaneous

Vehicles/pharmacology

Naphthalenes/administration & dosage/*pharmacokinetics

Chromatography

Humans

High Pressure Liquid

Propylene Glycol/*pharmacology

Glycols/*pharmacology

Gels

Skin Absorption/*drug effects

Administration

Antifungal Agents/administration & dosage/*pharmacokinetics

Författare

Hanne Evenbratt

Göteborgs universitet

Jan Faergemann

Göteborgs universitet

Acta Dermato-Venereologica

0001-5555 (ISSN) 1651-2057 (eISSN)

Vol. 89 126-9

Ämneskategorier

Dermatologi och venereologi

DOI

10.2340/00015555-0594