Control of high osmolarity signalling in the yeast Saccharomyces cerevisiae.
Review article, 2009
Signal transduction pathways control cellular responses to extrinsic and intrinsic signals. The yeast HOG (High Osmolarity Glycerol) response pathway mediates cellular adaptation to hyperosmotic stress. Pathway architecture as well as the flow of signal have been studied to a very high degree of detail. Recently, the yeast HOG pathway has become a popular model to analyse systems level properties of signal transduction. Those studies addressed, using experimentation and modelling, the role of basal signalling, robustness against perturbation, as well as adaptation and feedback control. These recent findings provide exciting insight into the higher control levels of signalling through this MAPK system of potential general importance.
pharmacology
Osmolar Concentration
Signal Transduction
pharmacology
Glycerol
Saccharomyces cerevisiae
Physiological
drug effects
physiology
Hypertonic Solutions
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Author
Stefan Hohmann
University of Gothenburg
FEBS letters
1873-3468 (ISSN)
Vol. 583 24 4025-9Subject Categories
Biochemistry and Molecular Biology
DOI
10.1016/j.febslet.2009.10.069
PubMed
19878680