Control of high osmolarity signalling in the yeast Saccharomyces cerevisiae.
Reviewartikel, 2009

Signal transduction pathways control cellular responses to extrinsic and intrinsic signals. The yeast HOG (High Osmolarity Glycerol) response pathway mediates cellular adaptation to hyperosmotic stress. Pathway architecture as well as the flow of signal have been studied to a very high degree of detail. Recently, the yeast HOG pathway has become a popular model to analyse systems level properties of signal transduction. Those studies addressed, using experimentation and modelling, the role of basal signalling, robustness against perturbation, as well as adaptation and feedback control. These recent findings provide exciting insight into the higher control levels of signalling through this MAPK system of potential general importance.

pharmacology

Osmolar Concentration

Signal Transduction

pharmacology

Glycerol

Saccharomyces cerevisiae

Physiological

drug effects

physiology

Hypertonic Solutions

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Författare

Stefan Hohmann

Göteborgs universitet

FEBS letters

1873-3468 (ISSN)

Vol. 583 24 4025-9

Ämneskategorier

Biokemi och molekylärbiologi

DOI

10.1016/j.febslet.2009.10.069

PubMed

19878680