Sealing of Submicrometer Wells by a Shear-Driven Lipid Bilayer
Journal article, 2010

A supported lipid bilayer (SLB) was formed in a microfluidic channel by vesicle fusion. The SLB, formed on a flat part of the surface, was driven by the shear forces of a bulk flow above the SLB to a part of the surface with embedded submicrometer wells. When using a bulk solution with a pH of 9.5 the advancing lipid bilayer sealed the wells, creating free-spanning membranes, whereas at a pH of 8.0 the SLB instead followed the contour of the wells.

microfluidics

SILICON

CHANNELS

molecule encapsulation

MONOLAYERS

SUPPORTED PHOSPHOLIPID-BILAYERS

MEMBRANES

KINETICS

Spreading lipid bilayers

HYDROPHILIC SURFACES

BIOSENSOR

NANOPORE ARRAYS

DIFFUSION

nanostructures

black lipid membranes

Author

Peter Jönsson

Chalmers, Applied Physics, Biological Physics

Magnus Jonsson

Chalmers, Applied Physics, Biological Physics

Fredrik Höök

Chalmers, Applied Physics, Biological Physics

Nano Letters

1530-6984 (ISSN) 1530-6992 (eISSN)

Vol. 10 5 1900-1906

Subject Categories

Physical Sciences

DOI

10.1021/nl100779k

More information

Created

10/7/2017