Sealing of Submicrometer Wells by a Shear-Driven Lipid Bilayer
Artikel i vetenskaplig tidskrift, 2010

A supported lipid bilayer (SLB) was formed in a microfluidic channel by vesicle fusion. The SLB, formed on a flat part of the surface, was driven by the shear forces of a bulk flow above the SLB to a part of the surface with embedded submicrometer wells. When using a bulk solution with a pH of 9.5 the advancing lipid bilayer sealed the wells, creating free-spanning membranes, whereas at a pH of 8.0 the SLB instead followed the contour of the wells.

microfluidics

SILICON

CHANNELS

molecule encapsulation

MONOLAYERS

SUPPORTED PHOSPHOLIPID-BILAYERS

MEMBRANES

KINETICS

Spreading lipid bilayers

HYDROPHILIC SURFACES

BIOSENSOR

NANOPORE ARRAYS

DIFFUSION

nanostructures

black lipid membranes

Författare

Peter Jönsson

Chalmers, Teknisk fysik, Biologisk fysik

Magnus Jonsson

Chalmers, Teknisk fysik, Biologisk fysik

Fredrik Höök

Chalmers, Teknisk fysik, Biologisk fysik

Nano Letters

1530-6984 (ISSN) 1530-6992 (eISSN)

Vol. 10 5 1900-1906

Ämneskategorier

Fysik

DOI

10.1021/nl100779k