Does indomethacin for closure of patent ductus arteriosus affect cerebral function?
Journal article, 2010

Abstract Objective: To study whether indomethacin used in conventional dose for closure of patent ductus arteriosus affects cerebral function measured by Electroencephalograms (EEG) evaluated by quantitative measures. Study design: Seven premature neonates with haemodynamically significant persistent ductus arteriosus were recruited. EEG were recorded before, during and after an intravenous infusion of 0.2 mg/kg indomethacin over 10 min. The EEG was analysed by two methods with different degrees of complexity for the amount of low-activity periods (LAP, "suppressions") as an indicator of affection of cerebral function. Results: Neither of the two methods identified any change in the amount of LAPs in the EEG as compared to before the indomethacin infusion. Conclusion: Indomethacin in conventional dose for closure of patent ductus arteriosus does not affect cerebral function as evaluated by quantitative EEG.


Anders Flisberg

University of Gothenburg

Ingemar Kjellmer

University of Gothenburg

Johan Löfhede

Chalmers, Signals and Systems, Signalbehandling och medicinsk teknik, Biomedical Signals and Systems

Nils Löfgren

Neoventa Medical AB

Manuel Rosa-Zurera

University of Alcalá

Kaj Lindecrantz

Royal Institute of Technology (KTH)

Magnus Thordstein

University of Gothenburg

Acta Paediatrica, International Journal of Paediatrics

0803-5253 (ISSN) 1651-2227 (eISSN)

Vol. 99 10 1493-1497

Subject Categories

Clinical Medicine

Pharmacology and Toxicology





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