Does indomethacin for closure of patent ductus arteriosus affect cerebral function?
Artikel i vetenskaplig tidskrift, 2010

Abstract Objective: To study whether indomethacin used in conventional dose for closure of patent ductus arteriosus affects cerebral function measured by Electroencephalograms (EEG) evaluated by quantitative measures. Study design: Seven premature neonates with haemodynamically significant persistent ductus arteriosus were recruited. EEG were recorded before, during and after an intravenous infusion of 0.2 mg/kg indomethacin over 10 min. The EEG was analysed by two methods with different degrees of complexity for the amount of low-activity periods (LAP, "suppressions") as an indicator of affection of cerebral function. Results: Neither of the two methods identified any change in the amount of LAPs in the EEG as compared to before the indomethacin infusion. Conclusion: Indomethacin in conventional dose for closure of patent ductus arteriosus does not affect cerebral function as evaluated by quantitative EEG.


Anders Flisberg

Göteborgs universitet

Ingemar Kjellmer

Göteborgs universitet

Johan Löfhede

Signaler och system, Signalbehandling och medicinsk teknik, Medicinska signaler och system

Nils Löfgren

Neoventa Medical AB

Manuel Rosa-Zurera

Universidad de Alcala

Kaj Lindecrantz

The Royal Institute of Technology (KTH)

Magnus Thordstein

Göteborgs universitet

Acta Paediatrica, International Journal of Paediatrics

0803-5253 (ISSN) 1651-2227 (eISSN)

Vol. 99 1493-1497


Klinisk medicin

Farmakologi och toxikologi