In vivo biomechanical stability of osseointegrating mesoporous TiO2 implants
Journal article, 2012

Mesoporous materials are of high interest as implant coatings to receive an enhanced osseointegration. In this study, titanium implants coated with mesoporous TiO(2) thin films have been evaluated both in vitro and in vivo. Material characterization showed that, with partly crystalline TiO(2) (anatase), long-range-ordered hydrophilic mesoporous thin films with a pore size of 6nm were obtained. Evaluation of the mechanical resistance showed that the films were robust enough to withstand the standard implantation procedure. In vitro apatite formation was studied using simulated body fluids, showing that the pores are accessible for ions and that formation of apatite was increased due to the presence of the mesopores. An in vivo study using a rabbit model was executed in which the removal torque and histomorphometry were evaluated. The results show that the biomechanical stability of the TiO(2) coating was unaffected by the presence of mesopores and that osseointegration was achieved without any signs of inflammation.

Mesoporous TiO2

Biomechanical stability





Johan Karlsson

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

Ryo Jimbo

Malmö university

Hoda Mashadi Fathali

Chalmers, Chemical and Biological Engineering, Analytical Chemistry

Humberto Osvaldo Schwartz-Filho

Malmö university

Mariko Hayashi

Malmö university

Mats Halvarsson

Chalmers, Applied Physics, Materials Microstructure

Ann Wennerberg

Malmö university

Martin Andersson

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

Acta Biomaterialia

1742-7061 (ISSN)

Vol. 8 12 4438-4446

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