Norovirus GII.4 Virus-like Particles Recognize Galactosylceramides in Domains of Planar Supported Lipid Bilayers.
Journal article, 2012

A sticky situation: Domain-dependent recognition of the glycosphingolipid galactosylceramide by norovirus-like particles (see picture; red/yellow) is shown using supported lipid bilayers (purple) as model membranes. Optimal ligand presentation is found to promote strong binding to GalCer. This presentation can be found at the edges of the glycosphingolipid-enriched domains (green) and binding is repressed in the absence of these domains.

Author

Marta Bally

Chalmers, Applied Physics, Biological Physics

Gustaf E Rydell

Centre national de la recherche scientifique (CNRS)

Raphael Zahn

Swiss Federal Institute of Technology in Zürich (ETH)

Waqas Nasir

University of Gothenburg

Christian Eggeling

University of Oxford

Max Planck Institute

Michael Breimer

University of Gothenburg

Lennart Svensson

Linköping University

Fredrik Höök

Chalmers, Applied Physics, Biological Physics

Göran Larson

University of Gothenburg

Angewandte Chemie - International Edition

1433-7851 (ISSN) 1521-3773 (eISSN)

Vol. 51 48 12020-4

Subject Categories

Cell and Molecular Biology

Other Basic Medicine

Biophysics

Microbiology in the medical area

DOI

10.1002/anie.201205972

PubMed

23097253

More information

Latest update

9/7/2018 1