Norovirus GII.4 Virus-like Particles Recognize Galactosylceramides in Domains of Planar Supported Lipid Bilayers.
Artikel i vetenskaplig tidskrift, 2012

A sticky situation: Domain-dependent recognition of the glycosphingolipid galactosylceramide by norovirus-like particles (see picture; red/yellow) is shown using supported lipid bilayers (purple) as model membranes. Optimal ligand presentation is found to promote strong binding to GalCer. This presentation can be found at the edges of the glycosphingolipid-enriched domains (green) and binding is repressed in the absence of these domains.

Författare

Marta Bally

Chalmers, Teknisk fysik, Biologisk fysik

Gustaf E Rydell

Centre national de la recherche scientifique (CNRS)

Raphael Zahn

Eidgenössische Technische Hochschule Zürich (ETH)

Waqas Nasir

Göteborgs universitet

Christian Eggeling

University of Oxford

Max Planck-institutet

Michael Breimer

Göteborgs universitet

Lennart Svensson

Linköpings universitet

Fredrik Höök

Chalmers, Teknisk fysik, Biologisk fysik

Göran Larson

Göteborgs universitet

Angewandte Chemie - International Edition

1433-7851 (ISSN) 1521-3773 (eISSN)

Vol. 51 48 12020-4

Ämneskategorier

Cell- och molekylärbiologi

Annan medicinsk grundvetenskap

Biofysik

Mikrobiologi inom det medicinska området

DOI

10.1002/anie.201205972

PubMed

23097253