Modeling yeast osmoadaptation at different levels of resolution
Review article, 2013
We review the proposed mathematical models of the response to osmotic stress in yeast. These models mainly differ in the choice of mathematical representation (e. g. Bayesian networks, ordinary differential equations, or rule-based models), the extent to which the modeling is data-driven, and predictability. The overview exemplifies how one biological system can be modeled with various modeling techniques and at different levels of resolution, and how the choice typically is based on the amount and quality of available data, prior information of the system, and the research question in focus. As a natural part of the overview, we discuss requirements, advantages, and limitations of the different modeling approaches.
yeast
glycerol
Osmotic stress
adaptation
systems
osmoregulation
saccharomyces-cerevisiae
osmotic-stress
hypotonic shock
networks
high osmolarity
mathematical modeling
signal-transduction pathway
Author
C. Kuhn
Humboldt University of Berlin
Peter Gennemark
Chalmers, Mathematical Sciences
University of Gothenburg
Uppsala University
Journal of Bioinformatics and Computational Biology
0219-7200 (ISSN) 17576334 (eISSN)
Vol. 11 2 artikel nr 1330001-Subject Categories
Biophysics
Bioinformatics and Systems Biology
DOI
10.1142/s0219720013300013