Modeling yeast osmoadaptation at different levels of resolution
Artikel i vetenskaplig tidskrift, 2013

We review the proposed mathematical models of the response to osmotic stress in yeast. These models mainly differ in the choice of mathematical representation (e. g. Bayesian networks, ordinary differential equations, or rule-based models), the extent to which the modeling is data-driven, and predictability. The overview exemplifies how one biological system can be modeled with various modeling techniques and at different levels of resolution, and how the choice typically is based on the amount and quality of available data, prior information of the system, and the research question in focus. As a natural part of the overview, we discuss requirements, advantages, and limitations of the different modeling approaches.

hypotonic shock

high osmolarity

mathematical modeling

adaptation

systems

networks

glycerol

saccharomyces-cerevisiae

Osmotic stress

signal-transduction pathway

osmotic-stress

yeast

osmoregulation

Författare

C. Kuhn

Peter Gennemark

Chalmers, Matematiska vetenskaper

Göteborgs universitet

Journal of Bioinformatics and Computational Biology

0219-7200 (ISSN)

Vol. 11 2 artikel nr 1330001-

Ämneskategorier

Biofysik

Bioinformatik och systembiologi

DOI

10.1142/s0219720013300013

Mer information

Skapat

2017-10-06