Clinically isolated syndromes with no further disease activity suggestive of multiple sclerosis at the age of population life expectancy
Journal article, 2014
The proportion of patients with clinically isolated syndrome (CIS) reported to convert to clinically definite multiple sclerosis varied between 30 and 75%. We studied the lifetime probability of remaining in the "CIS only" condition. The study was based on the longitudinally followed Gothenburg 1950-1964 incidence cohort (n = 306). Survival analysis revealed that 17.8% of 236 attack onset patients remained "CIS only". Patients with afferent (optic and sensory) symptoms had a better prognosis with approximately 30% of these patients remaining "CIS only". Patients who had experienced no relapse during the first 25 years remained "CIS only" for the subsequent 25 years of follow-up.
neuropsychology
multiple sclerosis
optic neuritis
magnetic resonance imaging
Clinically isolated syndrome
cohort
Author
Lenka Novakova
University of Gothenburg
Bengt Skoog
University of Gothenburg
Björn Runmarker
University of Gothenburg
Sven Ekholm
University of Rochester
Stefan Winblad
University of Gothenburg
Vera Lisovskaja
University of Gothenburg
Chalmers, Mathematical Sciences, Mathematical Statistics
Oluf Andersen
University of Gothenburg
Multiple Sclerosis
1352-4585 (ISSN) 1477-0970 (eISSN)
Vol. 20 4 496-500Subject Categories
Clinical Medicine
DOI
10.1177/1352458513496345