Clinically isolated syndromes with no further disease activity suggestive of multiple sclerosis at the age of population life expectancy
Artikel i vetenskaplig tidskrift, 2014

The proportion of patients with clinically isolated syndrome (CIS) reported to convert to clinically definite multiple sclerosis varied between 30 and 75%. We studied the lifetime probability of remaining in the "CIS only" condition. The study was based on the longitudinally followed Gothenburg 1950-1964 incidence cohort (n = 306). Survival analysis revealed that 17.8% of 236 attack onset patients remained "CIS only". Patients with afferent (optic and sensory) symptoms had a better prognosis with approximately 30% of these patients remaining "CIS only". Patients who had experienced no relapse during the first 25 years remained "CIS only" for the subsequent 25 years of follow-up.


multiple sclerosis

optic neuritis

magnetic resonance imaging

Clinically isolated syndrome



Lenka Novakova

Göteborgs universitet

Bengt Skoog

Göteborgs universitet

Björn Runmarker

Göteborgs universitet

Sven Ekholm

University of Rochester

Stefan Winblad

Göteborgs universitet

Vera Lisovskaja

Göteborgs universitet

Chalmers, Matematiska vetenskaper, Matematisk statistik

Oluf Andersen

Göteborgs universitet

Multiple Sclerosis

1352-4585 (ISSN) 1477-0970 (eISSN)

Vol. 20 4 496-500


Klinisk medicin



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