Genetic Variation in SULF2 Is Associated with Postprandial Clearance of Triglyceride-Rich Remnant Particles and Triglyceride Levels in Healthy Subjects.
Journal article, 2013
Nonfasting (postprandial) triglyceride concentrations have emerged as a clinically significant cardiovascular disease risk factor that results from accumulation of remnant triglyceride-rich lipoproteins (TRLs) in the circulation. The remnant TRLs are cleared from the circulation by hepatic uptake, but the specific mechanisms involved are unclear. The syndecan-1 heparan sulfate proteoglycan (HSPG) pathway is important for the hepatic clearance of remnant TRLs in mice, but its relevance in humans is unclear.
Author
Niina Matikainen
Maria A Burza
University of Gothenburg
Stefano Romeo
University of Gothenburg
Antti Hakkarainen
Martin Adiels
University of Gothenburg
Lasse Folkersen
Per Eriksson
Nina Lundbom
Ewa Ehrenborg
Marju Orho-Melander
Marja-Riitta Taskinen
Jan Borén
University of Gothenburg
PLoS ONE
1932-6203 (ISSN) 19326203 (eISSN)
Vol. 8 11 e79473-Subject Categories (SSIF 2011)
Basic Medicine
DOI
10.1371/journal.pone.0079473
PubMed
24278138