Genetic Variation in SULF2 Is Associated with Postprandial Clearance of Triglyceride-Rich Remnant Particles and Triglyceride Levels in Healthy Subjects.
Artikel i vetenskaplig tidskrift, 2013

Nonfasting (postprandial) triglyceride concentrations have emerged as a clinically significant cardiovascular disease risk factor that results from accumulation of remnant triglyceride-rich lipoproteins (TRLs) in the circulation. The remnant TRLs are cleared from the circulation by hepatic uptake, but the specific mechanisms involved are unclear. The syndecan-1 heparan sulfate proteoglycan (HSPG) pathway is important for the hepatic clearance of remnant TRLs in mice, but its relevance in humans is unclear.

Författare

Niina Matikainen

Maria A Burza

Göteborgs universitet

Stefano Romeo

Göteborgs universitet

Antti Hakkarainen

Martin Adiels

Göteborgs universitet

Lasse Folkersen

Per Eriksson

Nina Lundbom

Ewa Ehrenborg

Marju Orho-Melander

Marja-Riitta Taskinen

Jan Borén

Göteborgs universitet

PLoS ONE

1932-6203 (ISSN)

Vol. 8 e79473-

Ämneskategorier

Medicinska grundvetenskaper

DOI

10.1371/journal.pone.0079473

PubMed

24278138