Genetically Encoded Whole Cell Biosensor for Drug Discovery of HIF-1 Interaction Inhibitors
Journal article, 2022
directed evolution
high-throughput screen
new modality
drug discovery
genetic circuit
biosensor
Author
Louis Scott
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
AstraZeneca AB
Mark J. Wigglesworth
AstraZeneca AB
Verena Siewers
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Andy M. Davis
AstraZeneca AB
Florian David
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
ACS Synthetic Biology
2161-5063 (eISSN)
Vol. In PressSubject Categories
Pharmaceutical Sciences
Biochemistry and Molecular Biology
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
DOI
10.1021/acssynbio.2c00274
PubMed
36223492