N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, a molecule for radiohalogenation of proteins and peptides
Journal article, 2015

In this work a new coupling reagent, N[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, for radiohalogenation has been synthesized and characterized. The reagent is intended to either be attached to reduced disulfide bridges of proteins (making the halogenation site-specific) or to free terminal cysteine groups on peptides. The new reagent was also shown to be easily halogenated with inactive bromine and iodine as well as I-125 and At-211, indicating potential use within targeted radiotherapy.

Targeted radiotherapy

Halogenation

Electrophilic aromatic substitution

Peptide labelling

Site specific antibody labelling

Astatine-211

Author

Emma Aneheim

University of Gothenburg

Mark Foreman

Chalmers, Chemistry and Chemical Engineering, Energy and Material, Nuclear Chemistry

H. Jensen

Copenhagen University Hospital

Sture Lindegren

University of Gothenburg

Applied Radiation and Isotopes

0969-8043 (ISSN)

Vol. 96 1-5

Subject Categories

Chemical Sciences

DOI

10.1016/j.apradiso.2014.11.007

PubMed

25474765

More information

Latest update

1/30/2018