N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, a molecule for radiohalogenation of proteins and peptides
Artikel i vetenskaplig tidskrift, 2015

In this work a new coupling reagent, N[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, for radiohalogenation has been synthesized and characterized. The reagent is intended to either be attached to reduced disulfide bridges of proteins (making the halogenation site-specific) or to free terminal cysteine groups on peptides. The new reagent was also shown to be easily halogenated with inactive bromine and iodine as well as I-125 and At-211, indicating potential use within targeted radiotherapy.

Targeted radiotherapy

Halogenation

Electrophilic aromatic substitution

Peptide labelling

Site specific antibody labelling

Astatine-211

Författare

Emma Aneheim

Göteborgs universitet

Mark Foreman

Kemi och kemiteknik, Energi och material, Kärnkemi

H. Jensen

Copenhagen University Hospital

Sture Lindegren

Göteborgs universitet

Applied Radiation and Isotopes

0969-8043 (ISSN)

Vol. 96 1-5

Ämneskategorier

Kemi

DOI

10.1016/j.apradiso.2014.11.007

PubMed

25474765