Extracellular water and blood pressure in adults with growth hormone (GH) deficiency: a genotype-phenotype association study.
Journal article, 2014

Growth hormone deficiency (GHD) in adults is associated with decreased extracellular water volume (ECW). In response to GH replacement therapy (GHRT), ECW increases and blood pressure (BP) reduces or remains unchanged. Our primary aim was to study the association between polymorphisms in genes related to renal tubular function with ECW and BP before and 1 year after GHRT. The ECW measures using bioimpedance analysis (BIA) and bioimpedance spectroscopy (BIS) were validated against a reference method, the sodium bromide dilution method (Br(-)).

Author

Edna J L Barbosa

University of Gothenburg

Camilla A M Glad

University of Gothenburg

Anna G Nilsson

University of Gothenburg

Niklas Bosaeus

University of Gothenburg

Helena Filipsson Nyström

University of Gothenburg

Per-Arne Svensson

University of Gothenburg

Bengt-Åke Bengtsson

University of Gothenburg

Staffan Nilsson

Chalmers, Mathematical Sciences, Mathematical Statistics

University of Gothenburg

Ingvar Bosaeus

University of Gothenburg

Cesar Luiz Boguszewski

Universidade Federal do Parana

Gudmundur Johannsson

University of Gothenburg

PLoS ONE

1932-6203 (ISSN)

Vol. 9 8 e105754- e105754

Areas of Advance

Life Science Engineering (2010-2018)

Subject Categories

Other Medical and Health Sciences

DOI

10.1371/journal.pone.0105754

PubMed

25157616

More information

Created

10/7/2017