The cancer genome atlas pan-cancer analysis project
Review article, 2013

The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.

Author

John N. Weinstein

University of Texas MD Anderson Cancer Center

Eric A. Collisson

National Cancer Institute

Gordon B. Mills

University of California

Kenna R Mills Shaw

University of Texas MD Anderson Cancer Center

Brad A. Ozenberger

University of California

Kyle Ellrott

University of California

Chris Sander

Baylor College of Medicine

Joshua M. Stuart

University of California

Kyle Chang

British Columbia Cancer Agency

Chad J. Creighton

British Columbia Cancer Agency

Caleb Davis

British Columbia Cancer Agency

Lawrence Donehower

British Columbia Cancer Agency

Jennifer Drummond

British Columbia Cancer Agency

David Wheeler

British Columbia Cancer Agency

Adrian Ally

University of British Columbia (UBC)

Miruna Balasundaram

University of British Columbia (UBC)

Inanc Birol

University of British Columbia (UBC)

Yaron S.N. Butterfield

University of British Columbia (UBC)

Andy Chu

University of British Columbia (UBC)

Eric Chuah

University of British Columbia (UBC)

Hye-Jung E. Chun

University of British Columbia (UBC)

Noreen Dhalla

University of British Columbia (UBC)

Ranabir Guin

University of British Columbia (UBC)

Martin Hirst

University of British Columbia (UBC)

Carrie Hirst

University of British Columbia (UBC)

Robert A. Holt

University of British Columbia (UBC)

Steven J.M. Jones

University of British Columbia (UBC)

Darlene Lee

University of British Columbia (UBC)

Haiyan I. Li

University of British Columbia (UBC)

Marco A. Marra

University of British Columbia (UBC)

Michael Mayo

University of British Columbia (UBC)

Richard A. Moore

University of British Columbia (UBC)

Andrew J. Mungall

University of British Columbia (UBC)

A Gordon Robertson

University of British Columbia (UBC)

Jacqueline E. Schein

University of British Columbia (UBC)

Payal Sipahimalani

University of British Columbia (UBC)

Angela Tam

University of British Columbia (UBC)

Nina Thiessen

University of British Columbia (UBC)

Richard J. Varhol

University of British Columbia (UBC)

Rameen Beroukhim

Dana-Farber Cancer Institute

Ami S. Bhatt

Dana-Farber Cancer Institute

Angela N. Brooks

Dana-Farber Cancer Institute

Andrew D. Cherniack

Dana-Farber Cancer Institute

Samuel S. Freeman

Dana-Farber Cancer Institute

Stacey B. Gabriel

Dana-Farber Cancer Institute

Elena Helman

Dana-Farber Cancer Institute

Joonil Jung

Dana-Farber Cancer Institute

Matthew Meyerson

Dana-Farber Cancer Institute

Akinyemi I. Ojesina

Dana-Farber Cancer Institute

Chandra Sekhar Pedamallu

Dana-Farber Cancer Institute

Gordon Saksena

Dana-Farber Cancer Institute

Steven E. Schumacher

Dana-Farber Cancer Institute

Barbara Tabak

Dana-Farber Cancer Institute

Travis Zack

Dana-Farber Cancer Institute

Eric S. Lander

Dana-Farber Cancer Institute

Christopher A. Bristow

Harvard Medical School

Angela Hadjipanayis

Harvard Medical School

Psalm Haseley

Harvard Medical School

Raju Kucherlapati

Brigham and Women's Hospital

Semin Lee

Harvard Medical School

Eunjung Lee

Harvard Medical School

Lovelace J. Luquette

Harvard Medical School

Harshad S. Mahadeshwar

Harvard Medical School

Angeliki Pantazi

Harvard Medical School

Michael Parfenov

Harvard Medical School

Peter J. Park

Harvard Medical School

Alexei Protopopov

Harvard Medical School

Xiaojia Ren

Harvard Medical School

Netty Santoso

Harvard Medical School

Jonathan Seidman

Harvard Medical School

Sahil Seth

Harvard Medical School

Xingzhi Song

Harvard Medical School

Jiabin Tang

Harvard Medical School

Ruibin Xi

Harvard Medical School

Andrew W. Xu

Harvard Medical School

Lixing Yang

Harvard Medical School

Dong Zeng

Harvard Medical School

J Todd Auman

The University of North Carolina at Chapel Hill

Saianand Balu

The University of North Carolina at Chapel Hill

Elizabeth Buda

The University of North Carolina at Chapel Hill

Cheng Fan

The University of North Carolina at Chapel Hill

Katherine A. Hoadley

The University of North Carolina at Chapel Hill

Corbin D. Jones

The University of North Carolina at Chapel Hill

Shaowu Meng

The University of North Carolina at Chapel Hill

Piotr A. Mieczkowski

The University of North Carolina at Chapel Hill

Joel S Parker

The University of North Carolina at Chapel Hill

Charles M. Perou

The University of North Carolina at Chapel Hill

Jeffrey Roach

The University of North Carolina at Chapel Hill

Yan Shi

The University of North Carolina at Chapel Hill

Grace O. Silva

The University of North Carolina at Chapel Hill

Donghui Tan

The University of North Carolina at Chapel Hill

Umadevi Veluvolu

The University of North Carolina at Chapel Hill

Scot Waring

The University of North Carolina at Chapel Hill

Matthew D. Wilkerson

The University of North Carolina at Chapel Hill

Junyuan Wu

The University of North Carolina at Chapel Hill

Wei Zhao

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University

Tom Bodenheimer

The University of North Carolina at Chapel Hill

D Neil Hayes

The University of North Carolina at Chapel Hill

Alan P. Hoyle

The University of North Carolina at Chapel Hill

Stuart R. Jeffreys

The University of North Carolina at Chapel Hill

Lisle E. Mose

The University of North Carolina at Chapel Hill

Janae V. Simons

The University of North Carolina at Chapel Hill

Mathew G. Soloway

The University of North Carolina at Chapel Hill

Stephen B. Baylin

Johns Hopkins University

Benjamin P. Berman

Johns Hopkins University

Moiz S. Bootwalla

Johns Hopkins University

Ludmila Danilova

Massachusetts General Hospital

James G. Herman

University of Southern California

Toshinori Hinoue

Johns Hopkins University

Peter W. Laird

Johns Hopkins University

Suhn K. Rhie

Johns Hopkins University

Hui Shen

Johns Hopkins University

Timothy Triche

Johns Hopkins University

Daniel J. Weisenberger

Johns Hopkins University

Scott L. Carter

Dana-Farber Cancer Institute

Kristian Cibulskis

Dana-Farber Cancer Institute

Lynda Chin

Dana-Farber Cancer Institute

Jianhua Zhang

Harvard Medical School

Carrie Sougnez

Dana-Farber Cancer Institute

Min Wang

Dana-Farber Cancer Institute

Gad Getz

Dana-Farber Cancer Institute

Huyen Dinh

British Columbia Cancer Agency

Harsha Vardhan Doddapaneni

British Columbia Cancer Agency

Richard Gibbs

British Columbia Cancer Agency

Preethi Gunaratne

British Columbia Cancer Agency

Yi Han

British Columbia Cancer Agency

Divya Kalra

British Columbia Cancer Agency

Christie Kovar

British Columbia Cancer Agency

Lora Lewis

British Columbia Cancer Agency

Margaret Morgan

British Columbia Cancer Agency

Donna Morton

British Columbia Cancer Agency

Donna Muzny

British Columbia Cancer Agency

Jeffrey Reid

British Columbia Cancer Agency

Liu Xi

British Columbia Cancer Agency

Juok Cho

Dana-Farber Cancer Institute

Daniel Dicara

Dana-Farber Cancer Institute

Scott Frazer

Dana-Farber Cancer Institute

Nils Gehlenborg

Dana-Farber Cancer Institute

David I. Heiman

Dana-Farber Cancer Institute

Jaegil Kim

Dana-Farber Cancer Institute

Michael S. Lawrence

Dana-Farber Cancer Institute

Pei Lin

Dana-Farber Cancer Institute

Yingchun Liu

Dana-Farber Cancer Institute

Michael S. Noble

Dana-Farber Cancer Institute

Petar Stojanov

Dana-Farber Cancer Institute

Doug Voet

Dana-Farber Cancer Institute

Hailei Zhang

Dana-Farber Cancer Institute

Lihua Zou

Dana-Farber Cancer Institute

Chip Stewart

Dana-Farber Cancer Institute

Brady Bernard

Memorial Sloan-Kettering Cancer Center

Ryan Bressler

Memorial Sloan-Kettering Cancer Center

Andrea Eakin

Memorial Sloan-Kettering Cancer Center

Lisa Iype

Memorial Sloan-Kettering Cancer Center

Theo Knijnenburg

Memorial Sloan-Kettering Cancer Center

Roger Kramer

Memorial Sloan-Kettering Cancer Center

Richard Kreisberg

Memorial Sloan-Kettering Cancer Center

Kalle Leinonen

Memorial Sloan-Kettering Cancer Center

Jake Lin

Memorial Sloan-Kettering Cancer Center

Yuexin Liu

Baylor College of Medicine

Michael Miller

Memorial Sloan-Kettering Cancer Center

Sheila M. Reynolds

Memorial Sloan-Kettering Cancer Center

Hector Rovira

Memorial Sloan-Kettering Cancer Center

Ilya Shmulevich

Memorial Sloan-Kettering Cancer Center

Vesteinn Thorsson

Memorial Sloan-Kettering Cancer Center

Da Yang

University of Texas MD Anderson Cancer Center

Wei Zhang

Simon Fraser University

Samirkumar Amin

In Silico Solutions

Chang-Jiun Wu

Harvard Medical School

Chia-Chin Wu

Harvard Medical School

Rehan Akbani

University of Texas MD Anderson Cancer Center

Kenneth Aldape

Baylor College of Medicine

Keith A. Baggerly

University of Texas MD Anderson Cancer Center

Bradley Broom

Dana-Farber Cancer Institute

Tod D. Casasent

British Columbia Cancer Agency

James Cleland

University of British Columbia (UBC)

Deepti Dodda

Dana-Farber Cancer Institute

Mary Edgerton

Baylor College of Medicine

Leng Han

University of Texas MD Anderson Cancer Center

Shelley M. Herbrich

University of Texas MD Anderson Cancer Center

Zhenlin Ju

University of Texas MD Anderson Cancer Center

Hoon Kim

The Harvard-MIT Division of Health Sciences and Technology

Seth Lerner

The Harvard-MIT Division of Health Sciences and Technology

Jun Li

Baylor College of Medicine

Han Liang

Baylor College of Medicine

Wenbin Liu

Baylor College of Medicine

Philip L. Lorenzi

University of Texas MD Anderson Cancer Center

Yiling Lu

University of California

James Melott

University of Texas MD Anderson Cancer Center

Lam Nguyen

University of Texas MD Anderson Cancer Center

Xiaoping Su

University of Texas MD Anderson Cancer Center

Roeland Verhaak

University of Texas MD Anderson Cancer Center

Wenyi Wang

University of Texas MD Anderson Cancer Center

Andrew Wong

University of Texas MD Anderson Cancer Center

Yang Yang

University of Texas MD Anderson Cancer Center

Jun Yao

Baylor College of Medicine

Rong Yao

University of Texas MD Anderson Cancer Center

Kosuke Yoshihara

University of Texas MD Anderson Cancer Center

Yuan Yuan

University of Texas MD Anderson Cancer Center

Alfred K. Yung

Baylor College of Medicine

Nianxiang Zhang

University of Texas MD Anderson Cancer Center

Siyuan Zheng

University of Texas MD Anderson Cancer Center

Michael Ryan

University of California

David W. Kane

University of Texas MD Anderson Cancer Center

B Arman Aksoy

Baylor College of Medicine

Giovanni Ciriello

Baylor College of Medicine

Gideon Dresdner

Baylor College of Medicine

Jianjiong Gao

Baylor College of Medicine

Benjamin Gross

Baylor College of Medicine

Anders Jacobsen

Baylor College of Medicine

Andre Kahles

Memorial Sloan-Kettering Cancer Center

Marc Ladanyi

Baylor College of Medicine

William Lee

Baylor College of Medicine

Kjong-Van Lehmann

Baylor College of Medicine

Martin L. Miller

Baylor College of Medicine

Ricardo Ramirez

Baylor College of Medicine

Gunnar Rätsch

Baylor College of Medicine

Boris Reva

Baylor College of Medicine

Nikolaus Schultz

Baylor College of Medicine

Yasin Senbabaoglu

Baylor College of Medicine

Ronglai Shen

University of California

Rileen Sinha

Baylor College of Medicine

S Onur Sumer

Baylor College of Medicine

Yichao Sun

Baylor College of Medicine

Barry S. Taylor

National Cancer Institute

Nils Weinhold

Baylor College of Medicine

Suzanne Fei

Buck Institute for Research on Aging

Paul Spellman

Buck Institute for Research on Aging

Christopher Benz

University of California

Daniel Carlin

University of California

Melisssa Cline

University of California

Brian Craft

University of California

Mary Goldman

Brigham and Women's Hospital

David Haussler

University of California

Singer Ma

University of California

Sam Ng

University of California

Evan Paull

University of California

Amie Radenbaugh

University of California

Sofie Salama

University of California

Artem Sokolov

University of California

Teresa Swatloski

University of California

Vladislav Uzunangelov

University of California

Peter Waltman

University of California

Christina Yau

University of California

Jing Zhu

University of California

Stanley R. Hamilton

University of Texas MD Anderson Cancer Center

Scott Abbott

Washington University in St. Louis

Rachel Abbott

Washington University in St. Louis

Nathan D. Dees

Washington University in St. Louis

Kim Delehaunty

The University of Texas at Austin

Li Ding

Washington University in St. Louis

David J. Dooling

Washington University in St. Louis

Jim M. Eldred

Washington University in St. Louis

Catrina C. Fronick

Washington University in St. Louis

Robert Fulton

Washington University in St. Louis

Lucinda L. Fulton

Washington University in St. Louis

Joelle Kalicki-Veizer

Washington University in St. Louis

Krishna-Latha Kanchi

Washington University in St. Louis

Cyriac Kandoth

Washington University in St. Louis

Daniel C. Koboldt

Washington University in St. Louis

David E. Larson

Washington University in St. Louis

Timothy J. Ley

Washington University in St. Louis

Ling Lin

Washington University in St. Louis

Charles Lu

Washington University in St. Louis

Vincent J. Magrini

Washington University in St. Louis

Elaine R. Mardis

Scimentis

Michael D. McLellan

Sage Bionetworks

Joshua F. McMichael

Washington University in St. Louis

Christopher A. Miller

Washington University in St. Louis

Michelle O'Laughlin

Washington University in St. Louis

Craig Pohl

Washington University in St. Louis

Heather Schmidt

Washington University

Scott M. Smith

Washington University in St. Louis

Jason Walker

Washington University in St. Louis

John W. Wallis

Washington University in St. Louis

Michael C. Wendl

Washington University in St. Louis

Richard K. Wilson

Washington University in St. Louis

Todd Wylie

Washington University in St. Louis

Qunyuan Zhang

Washington University in St. Louis

Robert Burton

Memorial Sloan-Kettering Cancer Center

Mark A. Jensen

Memorial Sloan-Kettering Cancer Center

Ari Kahn

Memorial Sloan-Kettering Cancer Center

Todd Pihl

Memorial Sloan-Kettering Cancer Center

David Pot

Memorial Sloan-Kettering Cancer Center

Yunhu Wan

Memorial Sloan-Kettering Cancer Center

Douglas A. Levine

Research Institute at Nationwide Children's Hospital

Aaron D. Black

Ohio State University

Jay Bowen

Ohio State University

Jessica Frick

Ohio State University

Julie M. Gastier-Foster

Ohio State University

Hollie A. Harper

Ohio State University

Carmen Helsel

Ohio State University

Kristen M. Leraas

Ohio State University

Tara M. Lichtenberg

Ohio State University

Cynthia McAllister

Ohio State University

Nilsa C. Ramirez

Ohio State University

Samantha Sharpe

Ohio State University

Lisa Wise

Ohio State University

Erik Zmuda

Ohio State University

Stephen J. Chanock

Scimentis

Tanja Davidsen

Scimentis

John A. Demchok

Scimentis

Greg Eley

Sage Bionetworks

Ina Felau

Scimentis

Margi Sheth

Scimentis

Heidi Sofia

University of California

Louis Staudt

Scimentis

Roy Tarnuzzer

Scimentis

Zhining Wang

Scimentis

Liming Yang

Scimentis

Jiashan Zhang

Scimentis

Larsson Omberg

Brown University

Adam Margolin

Brown University

Benjamin J. Raphael

LLC

Fabio Vandin

LLC

Hsin-Ta Wu

LLC

Mark D.M. Leiserson

LLC

Stephen C. Benz

University of Sao Paulo (USP)

Charles J. Vaske

University of Sao Paulo (USP)

Houtan Noushmehr

University of Sao Paulo (USP)

Denise Wolf

Columbia University

Laura Van'T Veer

Columbia University

Dimitris Anastassiou

University Pompeu Fabra

Tai-Hsien Ou Yang

University Pompeu Fabra

Nuria Lopez-Bigas

Catalan Institution for Research and Advanced Studies

Abel Gonzalez-Perez

Catalan Institution for Research and Advanced Studies

David Tamborero

Catalan Institution for Research and Advanced Studies

Zheng Xia

National Library of Medicine

Wei Li

National Library of Medicine

Dong-Yeon Cho

Baylor College of Medicine

Teresa Przytycka

Baylor College of Medicine

Mark Hamilton

Uppsala University

Sean McGuire

Uppsala University

S. Nelander

Uppsala University

Patrik Johansson

University of Gothenburg

Rebecka Jörnsten

Uppsala University

Chalmers, Mathematical Sciences, Mathematical Statistics

Teresia Kling

University of Gothenburg

José Sánchez

Chalmers, Mathematical Sciences, Mathematical Statistics

Nature Genetics

1061-4036 (ISSN)

Vol. 45 10 1113-1120

Subject Categories

Medical Genetics

Bioinformatics and Systems Biology

Cancer and Oncology

DOI

10.1038/ng.2764

More information

Latest update

3/25/2023