The cancer genome atlas pan-cancer analysis project
Artikel i vetenskaplig tidskrift, 2013
The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
Författare
John N. Weinstein
University of Texas MD Anderson Cancer Center
Eric A. Collisson
National Cancer Institute
Gordon B. Mills
University of California
Kenna R Mills Shaw
University of Texas MD Anderson Cancer Center
Brad A. Ozenberger
University of California
Kyle Ellrott
University of California
Chris Sander
Baylor College of Medicine
Joshua M. Stuart
University of California
Kyle Chang
British Columbia Cancer Agency
Chad J. Creighton
British Columbia Cancer Agency
Caleb Davis
British Columbia Cancer Agency
Lawrence Donehower
British Columbia Cancer Agency
Jennifer Drummond
British Columbia Cancer Agency
David Wheeler
British Columbia Cancer Agency
Adrian Ally
University of British Columbia (UBC)
Miruna Balasundaram
University of British Columbia (UBC)
Inanc Birol
University of British Columbia (UBC)
Yaron S.N. Butterfield
University of British Columbia (UBC)
Andy Chu
University of British Columbia (UBC)
Eric Chuah
University of British Columbia (UBC)
Hye-Jung E. Chun
University of British Columbia (UBC)
Noreen Dhalla
University of British Columbia (UBC)
Ranabir Guin
University of British Columbia (UBC)
Martin Hirst
University of British Columbia (UBC)
Carrie Hirst
University of British Columbia (UBC)
Robert A. Holt
University of British Columbia (UBC)
Steven J.M. Jones
University of British Columbia (UBC)
Darlene Lee
University of British Columbia (UBC)
Haiyan I. Li
University of British Columbia (UBC)
Marco A. Marra
University of British Columbia (UBC)
Michael Mayo
University of British Columbia (UBC)
Richard A. Moore
University of British Columbia (UBC)
Andrew J. Mungall
University of British Columbia (UBC)
A Gordon Robertson
University of British Columbia (UBC)
Jacqueline E. Schein
University of British Columbia (UBC)
Payal Sipahimalani
University of British Columbia (UBC)
Angela Tam
University of British Columbia (UBC)
Nina Thiessen
University of British Columbia (UBC)
Richard J. Varhol
University of British Columbia (UBC)
Rameen Beroukhim
Dana-Farber Cancer Institute
Ami S. Bhatt
Dana-Farber Cancer Institute
Angela N. Brooks
Dana-Farber Cancer Institute
Andrew D. Cherniack
Dana-Farber Cancer Institute
Samuel S. Freeman
Dana-Farber Cancer Institute
Stacey B. Gabriel
Dana-Farber Cancer Institute
Elena Helman
Dana-Farber Cancer Institute
Joonil Jung
Dana-Farber Cancer Institute
Matthew Meyerson
Dana-Farber Cancer Institute
Akinyemi I. Ojesina
Dana-Farber Cancer Institute
Chandra Sekhar Pedamallu
Dana-Farber Cancer Institute
Gordon Saksena
Dana-Farber Cancer Institute
Steven E. Schumacher
Dana-Farber Cancer Institute
Barbara Tabak
Dana-Farber Cancer Institute
Travis Zack
Dana-Farber Cancer Institute
Eric S. Lander
Dana-Farber Cancer Institute
Christopher A. Bristow
Harvard Medical School
Angela Hadjipanayis
Harvard Medical School
Psalm Haseley
Harvard Medical School
Raju Kucherlapati
Brigham and Women's Hospital
Semin Lee
Harvard Medical School
Eunjung Lee
Harvard Medical School
Lovelace J. Luquette
Harvard Medical School
Harshad S. Mahadeshwar
Harvard Medical School
Angeliki Pantazi
Harvard Medical School
Michael Parfenov
Harvard Medical School
Peter J. Park
Harvard Medical School
Alexei Protopopov
Harvard Medical School
Xiaojia Ren
Harvard Medical School
Netty Santoso
Harvard Medical School
Jonathan Seidman
Harvard Medical School
Sahil Seth
Harvard Medical School
Xingzhi Song
Harvard Medical School
Jiabin Tang
Harvard Medical School
Ruibin Xi
Harvard Medical School
Andrew W. Xu
Harvard Medical School
Lixing Yang
Harvard Medical School
Dong Zeng
Harvard Medical School
J Todd Auman
The University of North Carolina at Chapel Hill
Saianand Balu
The University of North Carolina at Chapel Hill
Elizabeth Buda
The University of North Carolina at Chapel Hill
Cheng Fan
The University of North Carolina at Chapel Hill
Katherine A. Hoadley
The University of North Carolina at Chapel Hill
Corbin D. Jones
The University of North Carolina at Chapel Hill
Shaowu Meng
The University of North Carolina at Chapel Hill
Piotr A. Mieczkowski
The University of North Carolina at Chapel Hill
Joel S Parker
The University of North Carolina at Chapel Hill
Charles M. Perou
The University of North Carolina at Chapel Hill
Jeffrey Roach
The University of North Carolina at Chapel Hill
Yan Shi
The University of North Carolina at Chapel Hill
Grace O. Silva
The University of North Carolina at Chapel Hill
Donghui Tan
The University of North Carolina at Chapel Hill
Umadevi Veluvolu
The University of North Carolina at Chapel Hill
Scot Waring
The University of North Carolina at Chapel Hill
Matthew D. Wilkerson
The University of North Carolina at Chapel Hill
Junyuan Wu
The University of North Carolina at Chapel Hill
Wei Zhao
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University
Tom Bodenheimer
The University of North Carolina at Chapel Hill
D Neil Hayes
The University of North Carolina at Chapel Hill
Alan P. Hoyle
The University of North Carolina at Chapel Hill
Stuart R. Jeffreys
The University of North Carolina at Chapel Hill
Lisle E. Mose
The University of North Carolina at Chapel Hill
Janae V. Simons
The University of North Carolina at Chapel Hill
Mathew G. Soloway
The University of North Carolina at Chapel Hill
Stephen B. Baylin
Johns Hopkins University
Benjamin P. Berman
Johns Hopkins University
Moiz S. Bootwalla
Johns Hopkins University
Ludmila Danilova
Massachusetts General Hospital
James G. Herman
University of Southern California
Toshinori Hinoue
Johns Hopkins University
Peter W. Laird
Johns Hopkins University
Suhn K. Rhie
Johns Hopkins University
Hui Shen
Johns Hopkins University
Timothy Triche
Johns Hopkins University
Daniel J. Weisenberger
Johns Hopkins University
Scott L. Carter
Dana-Farber Cancer Institute
Kristian Cibulskis
Dana-Farber Cancer Institute
Lynda Chin
Dana-Farber Cancer Institute
Jianhua Zhang
Harvard Medical School
Carrie Sougnez
Dana-Farber Cancer Institute
Min Wang
Dana-Farber Cancer Institute
Gad Getz
Dana-Farber Cancer Institute
Huyen Dinh
British Columbia Cancer Agency
Harsha Vardhan Doddapaneni
British Columbia Cancer Agency
Richard Gibbs
British Columbia Cancer Agency
Preethi Gunaratne
British Columbia Cancer Agency
Yi Han
British Columbia Cancer Agency
Divya Kalra
British Columbia Cancer Agency
Christie Kovar
British Columbia Cancer Agency
Lora Lewis
British Columbia Cancer Agency
Margaret Morgan
British Columbia Cancer Agency
Donna Morton
British Columbia Cancer Agency
Donna Muzny
British Columbia Cancer Agency
Jeffrey Reid
British Columbia Cancer Agency
Liu Xi
British Columbia Cancer Agency
Juok Cho
Dana-Farber Cancer Institute
Daniel Dicara
Dana-Farber Cancer Institute
Scott Frazer
Dana-Farber Cancer Institute
Nils Gehlenborg
Dana-Farber Cancer Institute
David I. Heiman
Dana-Farber Cancer Institute
Jaegil Kim
Dana-Farber Cancer Institute
Michael S. Lawrence
Dana-Farber Cancer Institute
Pei Lin
Dana-Farber Cancer Institute
Yingchun Liu
Dana-Farber Cancer Institute
Michael S. Noble
Dana-Farber Cancer Institute
Petar Stojanov
Dana-Farber Cancer Institute
Doug Voet
Dana-Farber Cancer Institute
Hailei Zhang
Dana-Farber Cancer Institute
Lihua Zou
Dana-Farber Cancer Institute
Chip Stewart
Dana-Farber Cancer Institute
Brady Bernard
Memorial Sloan-Kettering Cancer Center
Ryan Bressler
Memorial Sloan-Kettering Cancer Center
Andrea Eakin
Memorial Sloan-Kettering Cancer Center
Lisa Iype
Memorial Sloan-Kettering Cancer Center
Theo Knijnenburg
Memorial Sloan-Kettering Cancer Center
Roger Kramer
Memorial Sloan-Kettering Cancer Center
Richard Kreisberg
Memorial Sloan-Kettering Cancer Center
Kalle Leinonen
Memorial Sloan-Kettering Cancer Center
Jake Lin
Memorial Sloan-Kettering Cancer Center
Yuexin Liu
Baylor College of Medicine
Michael Miller
Memorial Sloan-Kettering Cancer Center
Sheila M. Reynolds
Memorial Sloan-Kettering Cancer Center
Hector Rovira
Memorial Sloan-Kettering Cancer Center
Ilya Shmulevich
Memorial Sloan-Kettering Cancer Center
Vesteinn Thorsson
Memorial Sloan-Kettering Cancer Center
Da Yang
University of Texas MD Anderson Cancer Center
Wei Zhang
Simon Fraser University
Samirkumar Amin
In Silico Solutions
Chang-Jiun Wu
Harvard Medical School
Chia-Chin Wu
Harvard Medical School
Rehan Akbani
University of Texas MD Anderson Cancer Center
Kenneth Aldape
Baylor College of Medicine
Keith A. Baggerly
University of Texas MD Anderson Cancer Center
Bradley Broom
Dana-Farber Cancer Institute
Tod D. Casasent
British Columbia Cancer Agency
James Cleland
University of British Columbia (UBC)
Deepti Dodda
Dana-Farber Cancer Institute
Mary Edgerton
Baylor College of Medicine
Leng Han
University of Texas MD Anderson Cancer Center
Shelley M. Herbrich
University of Texas MD Anderson Cancer Center
Zhenlin Ju
University of Texas MD Anderson Cancer Center
Hoon Kim
The Harvard-MIT Division of Health Sciences and Technology
Seth Lerner
The Harvard-MIT Division of Health Sciences and Technology
Jun Li
Baylor College of Medicine
Han Liang
Baylor College of Medicine
Wenbin Liu
Baylor College of Medicine
Philip L. Lorenzi
University of Texas MD Anderson Cancer Center
Yiling Lu
University of California
James Melott
University of Texas MD Anderson Cancer Center
Lam Nguyen
University of Texas MD Anderson Cancer Center
Xiaoping Su
University of Texas MD Anderson Cancer Center
Roeland Verhaak
University of Texas MD Anderson Cancer Center
Wenyi Wang
University of Texas MD Anderson Cancer Center
Andrew Wong
University of Texas MD Anderson Cancer Center
Yang Yang
University of Texas MD Anderson Cancer Center
Jun Yao
Baylor College of Medicine
Rong Yao
University of Texas MD Anderson Cancer Center
Kosuke Yoshihara
University of Texas MD Anderson Cancer Center
Yuan Yuan
University of Texas MD Anderson Cancer Center
Alfred K. Yung
Baylor College of Medicine
Nianxiang Zhang
University of Texas MD Anderson Cancer Center
Siyuan Zheng
University of Texas MD Anderson Cancer Center
Michael Ryan
University of California
David W. Kane
University of Texas MD Anderson Cancer Center
B Arman Aksoy
Baylor College of Medicine
Giovanni Ciriello
Baylor College of Medicine
Gideon Dresdner
Baylor College of Medicine
Jianjiong Gao
Baylor College of Medicine
Benjamin Gross
Baylor College of Medicine
Anders Jacobsen
Baylor College of Medicine
Andre Kahles
Memorial Sloan-Kettering Cancer Center
Marc Ladanyi
Baylor College of Medicine
William Lee
Baylor College of Medicine
Kjong-Van Lehmann
Baylor College of Medicine
Martin L. Miller
Baylor College of Medicine
Ricardo Ramirez
Baylor College of Medicine
Gunnar Rätsch
Baylor College of Medicine
Boris Reva
Baylor College of Medicine
Nikolaus Schultz
Baylor College of Medicine
Yasin Senbabaoglu
Baylor College of Medicine
Ronglai Shen
University of California
Rileen Sinha
Baylor College of Medicine
S Onur Sumer
Baylor College of Medicine
Yichao Sun
Baylor College of Medicine
Barry S. Taylor
National Cancer Institute
Nils Weinhold
Baylor College of Medicine
Suzanne Fei
Buck Institute for Research on Aging
Paul Spellman
Buck Institute for Research on Aging
Christopher Benz
University of California
Daniel Carlin
University of California
Melisssa Cline
University of California
Brian Craft
University of California
Mary Goldman
Brigham and Women's Hospital
David Haussler
University of California
Singer Ma
University of California
Sam Ng
University of California
Evan Paull
University of California
Amie Radenbaugh
University of California
Sofie Salama
University of California
Artem Sokolov
University of California
Teresa Swatloski
University of California
Vladislav Uzunangelov
University of California
Peter Waltman
University of California
Christina Yau
University of California
Jing Zhu
University of California
Stanley R. Hamilton
University of Texas MD Anderson Cancer Center
Scott Abbott
Washington University in St. Louis
Rachel Abbott
Washington University in St. Louis
Nathan D. Dees
Washington University in St. Louis
Kim Delehaunty
The University of Texas at Austin
Li Ding
Washington University in St. Louis
David J. Dooling
Washington University in St. Louis
Jim M. Eldred
Washington University in St. Louis
Catrina C. Fronick
Washington University in St. Louis
Robert Fulton
Washington University in St. Louis
Lucinda L. Fulton
Washington University in St. Louis
Joelle Kalicki-Veizer
Washington University in St. Louis
Krishna-Latha Kanchi
Washington University in St. Louis
Cyriac Kandoth
Washington University in St. Louis
Daniel C. Koboldt
Washington University in St. Louis
David E. Larson
Washington University in St. Louis
Timothy J. Ley
Washington University in St. Louis
Ling Lin
Washington University in St. Louis
Charles Lu
Washington University in St. Louis
Vincent J. Magrini
Washington University in St. Louis
Elaine R. Mardis
Scimentis
Michael D. McLellan
Sage Bionetworks
Joshua F. McMichael
Washington University in St. Louis
Christopher A. Miller
Washington University in St. Louis
Michelle O'Laughlin
Washington University in St. Louis
Craig Pohl
Washington University in St. Louis
Heather Schmidt
Washington University
Scott M. Smith
Washington University in St. Louis
Jason Walker
Washington University in St. Louis
John W. Wallis
Washington University in St. Louis
Michael C. Wendl
Washington University in St. Louis
Richard K. Wilson
Washington University in St. Louis
Todd Wylie
Washington University in St. Louis
Qunyuan Zhang
Washington University in St. Louis
Robert Burton
Memorial Sloan-Kettering Cancer Center
Mark A. Jensen
Memorial Sloan-Kettering Cancer Center
Ari Kahn
Memorial Sloan-Kettering Cancer Center
Todd Pihl
Memorial Sloan-Kettering Cancer Center
David Pot
Memorial Sloan-Kettering Cancer Center
Yunhu Wan
Memorial Sloan-Kettering Cancer Center
Douglas A. Levine
Research Institute at Nationwide Children's Hospital
Aaron D. Black
Ohio State University
Jay Bowen
Ohio State University
Jessica Frick
Ohio State University
Julie M. Gastier-Foster
Ohio State University
Hollie A. Harper
Ohio State University
Carmen Helsel
Ohio State University
Kristen M. Leraas
Ohio State University
Tara M. Lichtenberg
Ohio State University
Cynthia McAllister
Ohio State University
Nilsa C. Ramirez
Ohio State University
Samantha Sharpe
Ohio State University
Lisa Wise
Ohio State University
Erik Zmuda
Ohio State University
Stephen J. Chanock
Scimentis
Tanja Davidsen
Scimentis
John A. Demchok
Scimentis
Greg Eley
Sage Bionetworks
Ina Felau
Scimentis
Margi Sheth
Scimentis
Heidi Sofia
University of California
Louis Staudt
Scimentis
Roy Tarnuzzer
Scimentis
Zhining Wang
Scimentis
Liming Yang
Scimentis
Jiashan Zhang
Scimentis
Larsson Omberg
Brown University
Adam Margolin
Brown University
Benjamin J. Raphael
LLC
Fabio Vandin
LLC
Hsin-Ta Wu
LLC
Mark D.M. Leiserson
LLC
Stephen C. Benz
Universidade de Sao Paulo (USP)
Charles J. Vaske
Universidade de Sao Paulo (USP)
Houtan Noushmehr
Universidade de Sao Paulo (USP)
Denise Wolf
Columbia University
Laura Van'T Veer
Columbia University
Dimitris Anastassiou
Universitat Pompeu Fabra
Tai-Hsien Ou Yang
Universitat Pompeu Fabra
Nuria Lopez-Bigas
Institucio Catalana de Recerca i Estudis Avancats
Abel Gonzalez-Perez
Institucio Catalana de Recerca i Estudis Avancats
David Tamborero
Institucio Catalana de Recerca i Estudis Avancats
Zheng Xia
National Library of Medicine
Wei Li
National Library of Medicine
Dong-Yeon Cho
Baylor College of Medicine
Teresa Przytycka
Baylor College of Medicine
Mark Hamilton
Uppsala universitet
Sean McGuire
Uppsala universitet
S. Nelander
Uppsala universitet
Patrik Johansson
Göteborgs universitet
Rebecka Jörnsten
Chalmers, Matematiska vetenskaper, Matematisk statistik
Uppsala universitet
Teresia Kling
Göteborgs universitet
José Sánchez
Chalmers, Matematiska vetenskaper, Matematisk statistik
Nature Genetics
1061-4036 (ISSN) 15461718 (eISSN)
Vol. 45 10 1113-1120Ämneskategorier
Medicinsk genetik
Bioinformatik och systembiologi
Cancer och onkologi
DOI
10.1038/ng.2764