Absolute Asymmetric Synthesis: Protected Substrate Oxidation
Journal article, 2015

Three new conglomerates incorporating bidentate sulfide ligands coordinated by Ru-II centers have been prepared. Total spontaneous resolution by slow crystallization gives highly enantioenriched crystal batches, which are used in enantioselective oxidation of the sulfide ligands to give chiral sulfoxide complexes with >98% ee. All relevant stereoisomers have been characterized by single-crystal X-ray diffraction, CD spectroscopy, and chiral HPLC. If the ligand range can be extended to monodentate sulfides, a large-scale and recyclable process for enantioselective oxidation of sulfides can be designed.

sulfur ligands

crystal growth

ruthenium

oxidation

asymmetric synthesis

Author

Susanne Olsson

University of Gothenburg

Per Martin Björemark

University of Gothenburg

Theonitsa Kokoli

University of Gothenburg

J. Sundberg

University of Southern Denmark

Anders Lennartsson

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Polymer Technology

C. J. McKenzie

University of Southern Denmark

Mikael Håkansson

University of Gothenburg

Chemistry - A European Journal

0947-6539 (ISSN) 1521-3765 (eISSN)

Vol. 21 13 5211-5219

Subject Categories

Inorganic Chemistry

DOI

10.1002/chem.201406354

More information

Latest update

9/6/2018 1