Absolute Asymmetric Synthesis: Protected Substrate Oxidation
Artikel i vetenskaplig tidskrift, 2015

Three new conglomerates incorporating bidentate sulfide ligands coordinated by Ru-II centers have been prepared. Total spontaneous resolution by slow crystallization gives highly enantioenriched crystal batches, which are used in enantioselective oxidation of the sulfide ligands to give chiral sulfoxide complexes with >98% ee. All relevant stereoisomers have been characterized by single-crystal X-ray diffraction, CD spectroscopy, and chiral HPLC. If the ligand range can be extended to monodentate sulfides, a large-scale and recyclable process for enantioselective oxidation of sulfides can be designed.

ruthenium

asymmetric synthesis

oxidation

sulfur ligands

crystal growth

Författare

Susanne Olsson

Göteborgs universitet

Per Martin Björemark

Göteborgs universitet

Theonitsa Kokoli

Göteborgs universitet

J. Sundberg

Syddansk Universitet

Anders Lennartsson

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Polymerteknologi

C. J. McKenzie

Syddansk Universitet

Mikael Håkansson

Göteborgs universitet

Chemistry - A European Journal

0947-6539 (ISSN) 1521-3765 (eISSN)

Vol. 21 13 5211-5219

Ämneskategorier

Oorganisk kemi

DOI

10.1002/chem.201406354