Single Particle Nanoplasmonic Sensing in Individual Nanofluidic Channels
Journal article, 2016

Nanoplasmonics allows label-free optical sensing and spectroscopy at the single nanoparticle level by exploiting plasmonic excitations in metal nanoparticles. Nanofluidics offers exclusive possibilities for applying and controlling fluid flow and mass transport at the nanoscale and toward nanosized objects. Here, we combine these two concepts in a single device, by integrating single particle nanoplasmonic sensing with nanofluidics using advanced nanofabrication. The developed devices enable on-chip referenced parallel single particle nanoplasmonic sensing inside multiple individual nanofluidic channels with dimensions down to the 100 nm range. Beyond detailed discussion of the nanofabrication, general device characterization, and parallelized single particle plasmonic readout concepts, we demonstrate device function on two examples: (i) in situ measurements of local buffer concentrations inside a nanofluidic channel; (ii) real time binding kinetics of alkanethiol molecules to a single plasmonic nanonatenna sensor in a single nanochannel. Our concept thus provides a powerful solution for controlling mass transport to and from individual (plasmonic) nanoparticles, which in a long-term perspective offers unique opportunities for label-free detection of analyte molecules at low concentrations and for fundamental studies of fluids in extreme confinement.


Single particle plasmonic sensing

dark-field scattering spectroscopy

parallelized single particle plasmonic readout




Joachim Fritzsche

Chalmers, Physics, Chemical Physics

David Albinsson

Chalmers, Physics, Chemical Physics

Michael Fritzsche

Tomasz Antosiewicz

Chalmers, Physics, Bionanophotonics

Fredrik Westerlund

Chalmers, Biology and Biological Engineering, Chemical Biology

Christoph Langhammer

Chalmers, Physics, Chemical Physics

Nano Letters

1530-6984 (ISSN) 1530-6992 (eISSN)

Vol. 16 12 7857-7864

Areas of Advance

Nanoscience and Nanotechnology

Subject Categories

Atom and Molecular Physics and Optics

Condensed Matter Physics



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4/5/2022 1