Serum levels of Vitamin A and Atopic Rhinoconjunctivitis in Swedish adolescents
Journal article, 2017

Aim: Vitamin A plays a role in mucosal immunity and tolerance, but the association between vitamin A status and allergy is still unclear. The aim of the study was to analyze the levels of vitamin A in serum from adolescents with or without atopic rhinoconjunctivitis. Method: Thirteen-year-old children with atopic rhinoconjunctivitis (n = 53) and non-allergic, non-sensitized controls (n = 52) were randomly selected from a population based prospective birth cohort comprising 1228 children in Northern Sweden born in 1996-1997. Vitamin A (retinol) concentrations in serum were measured with high performance liquid chromatography mass spectrometry. Multiple logistic regression was used to evaluate the association between allergy prevalence and serum vitamin A levels. Results: Multiple logistic regression analysis showed no association between serum vitamin A levels and atopic rhinoconjunctivitis prevalence; OR = 1.00 (95% confidence interval 1.00-1.00), p = 0.81. Stratification for gender revealed a trend for a higher risk for having atopic rhinoconjunctivitis with higher concentrations of vitamin A in serum for females, OR = 1.02 (1.00-1.05), p = 0.07. No such associations were found in male subjects OR = 0.99 (0.97-1.01), p = 0.15. A dose-response relationship between allergy and vitamin A concentrations were also calculated but no such relationships were found, neither for all subjects nor for male and females separately. Conclusions: Serum levels of vitamin A could neither be positively nor negatively associated with atopic rhinoconjunctivitis in Swedish teenagers.

Vitamin A.

Atopic rhinoconjunctivitis

Retinol

Author

Malin Barman

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Nils-Gunnar Carlsson

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Anna Sandin

Agnes E Wold

University of Gothenburg

Ann-Sofie Sandberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Journal of Food Science and Nutrition Therapy

Vol. 3 1 014-019

Subject Categories

Immunology

Biological Sciences

Respiratory Medicine and Allergy

Nutrition and Dietetics

Areas of Advance

Life Science Engineering (2010-2018)

More information

Created

10/8/2017