Serum levels of Vitamin A and Atopic Rhinoconjunctivitis in Swedish adolescents
Journal article, 2017

Aim: Vitamin A plays a role in mucosal immunity and tolerance, but the association between vitamin A status and allergy is still unclear. The aim of the study was to analyze the levels of vitamin A in serum from adolescents with or without atopic rhinoconjunctivitis. Method: Thirteen-year-old children with atopic rhinoconjunctivitis (n = 53) and non-allergic, non-sensitized controls (n = 52) were randomly selected from a population based prospective birth cohort comprising 1228 children in Northern Sweden born in 1996-1997. Vitamin A (retinol) concentrations in serum were measured with high performance liquid chromatography mass spectrometry. Multiple logistic regression was used to evaluate the association between allergy prevalence and serum vitamin A levels. Results: Multiple logistic regression analysis showed no association between serum vitamin A levels and atopic rhinoconjunctivitis prevalence; OR = 1.00 (95% confidence interval 1.00-1.00), p = 0.81. Stratification for gender revealed a trend for a higher risk for having atopic rhinoconjunctivitis with higher concentrations of vitamin A in serum for females, OR = 1.02 (1.00-1.05), p = 0.07. No such associations were found in male subjects OR = 0.99 (0.97-1.01), p = 0.15. A dose-response relationship between allergy and vitamin A concentrations were also calculated but no such relationships were found, neither for all subjects nor for male and females separately. Conclusions: Serum levels of vitamin A could neither be positively nor negatively associated with atopic rhinoconjunctivitis in Swedish teenagers.


Atopic rhinoconjunctivitis

Vitamin A.


Malin Barman

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Nils-Gunnar Carlsson

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Anna Sandin

Umeå University

Agnes E Wold

University of Gothenburg

Ann-Sofie Sandberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Journal of food science and nutrition therapy

2641-3043 (ISSN)

Vol. 3 1 014-019

Subject Categories


Biological Sciences

Respiratory Medicine and Allergy

Nutrition and Dietetics

Areas of Advance

Life Science Engineering (2010-2018)

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