The major theme in Professor Sandberg’s research is the utilization of biological techniques to improve nutrient properties or physiological function of foods or food components. This includes development of analytical methods, in vitro and in vivo models for the estimation of bioavailability of nutrients (mostly minerals) and bioactivity of compounds in foods. She is investigating effects of bioactive compounds, mainly from marine foods, on risk factors for cardiovascular disease, the process of aging and allergy development, through well-designed diet intervention studies in humans or animal models. The molecular mechanisms behind are also of major concern. Ann-Sofie Sandberg’s research bridges food science with medicine.
Showing 208 publications
Mediation by Thyroid Hormone in the Relationships Between Gestational Exposure to Methylmercury and Birth Size
Identification of metabotypes in complex biological data using tensor decomposition
Biomarkers of seafood intake during pregnancy – Pollutants versus fatty acids and micronutrients
Differences between Arterial and Venous Umbilical Cord Plasma Metabolome and Association with Parity
Association of maternal urinary fluoride concentrations during pregnancy with size at birth and the potential mediation effect by maternal thyroid hormones: The Swedish NICE birth cohort
Identifying metabotypes from tensor data
Pilot-Scale Protein Recovery from Cold-Pressed Rapeseed Press Cake: Influence of Solids Recirculation
Assessment of Joint Impact of Iodine, Selenium, and Zinc Status on Women's Third-Trimester Plasma Thyroid Hormone Concentrations
Nutritional Composition and Estimated Iron and Zinc Bioavailability of Meat Substitutes Available on the Swedish Market
Lower Non-Heme Iron Absorption in Healthy Females from Single Meals with Texturized Fava Bean Protein Compared to Beef and Cod Protein Meals: Two Single-Blinded Randomized Trials
Protein extraction from cold-pressed hempseed press cake: From laboratory to pilot scale
Maternal characteristics and pregnancy outcomes in the NICE birth cohort: an assessment of self-selection bias
Thyroid hormones in relation to toxic metal exposure in pregnancy, and potential interactions with iodine and selenium
Identifying metabotypes from complex biological data using PARAFAC
Proportions of polyunsaturated fatty acids in umbilical cord blood at birth are related to atopic eczema development in the first year of life
Associations of maternal and infant metabolomes with immune maturation and allergy development at 12 months in the Swedish NICE-cohort
Umbilical cord blood metabolome differs in relation to delivery mode, birth order and sex, maternal diet and possibly future allergy development in rural children
Nutritional and antinutritional composition of fava bean (Vicia faba L., var. minor) cultivars
Infant Iodine and Selenium Status in Relation to Maternal Status and Diet During Pregnancy and Lactation
Potential Negative Effects of Whole grain Consumption
The development of a novel ferric phytate compound for iron fortification of bouillons (part I)
Isolation, identification, and selection of strains as candidate probiotics and starters for fermentation of Swedish legumes
Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema
Low-level maternal exposure to cadmium, lead, and mercury and birth outcomes in a Swedish prospective birth-cohort
Maternal Intake of Cow's Milk during Lactation Is Associated with Lower Prevalence of Food Allergy in Offspring
Reply to the comments by Vorland et al. on our paper: “low-phytate wholegrain bread instead of high-phytate wholegrain bread in a total diet context did not improve iron status of healthy Swedish females: a 12-week, randomized, parallel-design intervention study”
Cord Blood Levels of EPA, a Marker of Fish Intake, Correlate with Infants' T- and B-Lymphocyte Phenotypes and Risk for Allergic Disease
Low-phytate wholegrain bread instead of high-phytate wholegrain bread in a total diet context did not improve iron status of healthy Swedish females: a 12-week, randomized, parallel-design intervention study
Food and Nutrient Intake during Pregnancy in Relation to Maternal Characteristics: Results from the NICE Birth Cohort in Northern Sweden.
Effect of fermentation and dry roasting on the nutritional quality and sensory attributes of quinoa
Exposure to a Farm Environment During Pregnancy Increases the Proportion of Arachidonic Acid in the Cord Sera of Offspring
The Omega-3 Fatty Acids EPA and DHA, as a Part of a Murine High-Fat Diet, Reduced Lipid Accumulation in Brown and White Adipose Tissues.
Enzyme pre-treatment of soy bean meal:effects on non-starch carbohydrates, protein,phytic acid, and saponin biotransformation and digestibility in mink (Neovison vison)
Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden
Enzyme pre-treatment of soybean meal: Effects on non-starch carbohydrates, protein, phytic acid, and saponin biotransformation and digestibility in mink (Neovison vison)
Circulating Linoleic Acid is Associated with Improved Glucose Tolerance in Women after Gestational Diabetes
Iron Supplements Containing Lactobacillus plantarum 299v Increase Ferric Iron and Up-regulate the Ferric Reductase DCYTB in Human Caco-2/HT29 MTX Co-Cultures
Serum levels of Vitamin A and Atopic Rhinoconjunctivitis in Swedish adolescents
Dietary Protein Sources Beyond Proteins and Amino Acids - A Comparative Study of the Small Molecular Weight Components of Meat and Fish using Metabolomics
Late introduction of fish and eggs is associated with increased risk of allergy development - results from the FARMFLORA birth cohort
Biomarkers for predicting type 2 diabetes development-Can metabolomics improve on existing biomarkers?
Splenic Immune Response Is Down-Regulated in C57BL/6J Mice Fed Eicosapentaenoic Acid and Docosahexaenoic Acid Enriched High Fat Diet
Biomarkers of food intake and nutrient status are associated with glucose tolerance status and development of type 2 diabetes in older Swedish women
Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women.
Biomarkers of food intake and nutrient status are associated with glucose tolerance status and development of Type 2 diabetes
Fat intake and breast milk fatty acid composition in farming and nonfarming women and allergy development in the offspring.
Six Tissue Transcriptomics Reveals Specific Immune Suppression in Spleen by Dietary Polyunsaturated Fatty Acids
Serum fatty acids in infants, reflecting family fish consumption, were inversely associated with allergy development but not related to farm residence.
Diet in 1-year-old farm and control children and allergy development: results from the FARMFLORA birth cohort
Eicosapentaenoic and Docosahexaenoic Acid-Enriched High Fat Diet Delays Skeletal Muscle Degradation in Mice
A Simultaneous Metabolic Profiling and Quantitative Multimetabolite Metabolomic Method for Human Plasma Using Gas-Chromatography Tandem Mass Spectrometry.
A high-throughput method for liquid chromatography-tandem mass spectrometry determination of plasma alkylresorcinols, biomarkers of whole grain wheat and rye intake.
The effects of hydrothermal processing and germination on Fe speciation and Fe bioaccessibility to human intestinal Caco-2 cells in Tartary buckwheat
Phytic acid - Properties, Uses and Determination
Increased iron bioavailability from lactic fermented vegetables is likely an effect of promoting the formation of ferric iron
A randomized longitudinal dietary intervention study during pregnancy: effects on fish intake, phospholipids, and body composition
Eicosapentaenoic and docosahexaenoic acid-enriched high fat diet delays the development of fatty liver in mice
Herring and beef meals lead to differences in plasma 2-aminoaidipic acid, β-alanine, 4-hydroxyproline, cetoleic acid and docosahexaenoic acid concentrations in overweight men
Habitual high intake of fatty fish is related to lower levels of F2-isoprostanes in healthy females
Postprandial lipid and insulin responses among healthy, overweight men to mixed meals served with baked herring, pickled herring or baked, minced beef
Mat från havet ska göra oss friskare
Increased Ferric Iron Species in Lactic Fermented Vegetables May Improve Iron Absorption
Phytate, zinc, iron and calcium content of common Bolivian food, and implications for mineral bioavailability
Single nucleotide polymorphisms in fatty acid desaturases is associated with cord blood long chain PUFA proportions and development of allergy
Sourdough fermentation of wheat flour does not prevent the interaction of transglutaminase 2 with α2-gliadin or gluten.
No association between allergy and current 25-hydroxy vitamin D in serum or vitamin D intake
The Polyunsaturated Fatty Acids Arachidonic Acid and Docosahexaenoic Acid Induce Mouse Dendritic Cells Maturation but Reduce T-Cell Responses In Vitro
Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort).
Postprandial plasma differences after beef and herring based meals in 2-aminoaidipic acid, beta-alanine, 4-hydroxyproline, cetoleic acid and docosahexaenoic acid: a metabolomics study
High proportions of eicosapentaenoic acid (EPA) in infants' serum may decrease allergy risk: results from the FARMFLORA birth-cohort
Serum fatty acid profile does not reflect seafood intake in adolescents with atopic eczema.
Taurine may affect redox homeostasis via regulation of thioredoxin interacting protein in endothelial cells
Ascorbate-induced iron transport through ferroportin involves IRP2 and HIF2 alpha
Proposing a Caco-2/HepG2 cell model for in vitro iron absorption studies
Iron Transport through Ferroportin Is Induced by Intracellular Ascorbate and Involves IRP2 and HIF2 alpha
A new approach to measuring vitamin D in human adipose tissue using time-of-flight secondary ion mass spectrometry: A pilot study
Vitamin B12 as a potential compliance marker for fish intake
High Levels of Both n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids in Cord Serum Phospholipids Predict Allergy Development
Improvement of the intestinal Caco-2 cell model for iron absorption studies by the introduction of liver (HepG2) cells
A maternal diet of fatty fish reduces body fat of offspring compared with a maternal diet of beef and a post-weaning diet of fish improves insulin sensitivity and lipid profile in adult C57BL/6 male mice.
Usefulness of microbial phytase to improve zinc and iron bioavailability
The iron transporter ferroportin is regulated by ascorbate
Renare närmiljö och kost kan förklara ökning av allergier
In vitro and in vivo degradation of myo-inositol hexakisphosphate by a phytase from Citrobacter braakii
Dephytinisation of Sangak and Barbari bread made from different extraction rate flours increases iron and zinc bioaccessibility in Caco-2 cells
Dietary herring improves plasma lipid profiles and reduces atherosclerosis in obese low-density lipoprotein receptor-deficient mice
Developing functional ingredients: a case study of pea protein
Identification of gliadin-binding peptides by phage display
Iron regulates the uptake of ascorbic acid and the expression of sodium-dependent vitamin C transporter 1 (SVCT1) in human intestinal Caco-2 cells
Low breast milk levels of long-chain n-3 fatty acids in allergic women, despite frequent fish intake
In vitro digestive stability of complexes between gliadin and synthetic blocking peptides
Long-chain polyunsaturated fatty acids are consumed during allergic inflammation and affect T helper type 1 (Th1)- and Th2-mediated hypersensitivity differently
Identifying molecular effects of diet through systems biology: influence of herring diet on sterol metabolism and protein turnover in mice
The Use of Caco-2 Cells to Estimate Fe Absorption in Humans - a Critical Appraisal
Determination of Fe2+ and Fe3+ in aqueous solutions containing food chelators by differential pulse anodic stripping voltammetry
Nonlinear microscopy of lipid storage and fibrosis in muscle and liver tissues of mice fed high-fat diets
Blocking peptides decrease tissue transglutaminase processing of gliadin in vitro
Influence of herring (Clupea harengus) and herring fractions on metabolic status in rats fed a high energy diet.
Impaired uptake of beta-carotene by Caco-2 human intestinal cells in the presence of iron
Phytate degradation by human gut isolated Bifidobacterium pseudocatenulatum ATCC27919 and its probiotic potential
Plasma phospholipid EPA and DHA in relation to atherosclerosis in 61-year-old men
Herring (Clupea harengus) intake influences lipoproteins but not inflammatory and oxidation markers in overweight men
Tempe Fermentation of Whole Grain Barley Increased Human Iron Absorption and In vitro Iron Availability
Ascorbic acid uptake affects ferritin, Dcytb and Nramp2 expression in Caco-2 cells
Aqueous fish extract increases survival in the mouse model of cytostatic toxicity
Peniophora lycii phytase is stabile and degrades phytate and solubilises minerals in vitro during simulation of gastrointestinal digestion in the pig
Changes in the Antioxidative Property of Herring (Clupea harengus) Press Juice during a Simulated Gastrointestinal Digestion
Herring (Clupea harengus) supplemented diet influence risk factors for CVD in overweight subjects
Interaction of phytate with protein and minerals in a soybean-maize meal blend depends on pH and calcium addition
Evaluation of Occasional Nonresponse of a Washed Cod Mince Model to Hemoglobin (Hb)-Mediated Oxidation
The type of thermal feed treatment influences the inositol phosphate composition
Antioxidative Properties of Press Juice From Herring (Clupea harengus) Against Hemoglobin (Hb) Mediated Oxidation of Washed Cod Mince
Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate
Inhibitory effect of known antioxidants and of press juice from herring (Clupea harengus) light muscle on the generation of free radicals in human monocytes
Reduction of phytate content while preserving minerals during whole grain cereal tempe fermentation
Lactic acid fermentation stimulated iron absorption by Caco-2 cells is associated with increased soluble Fe2+ content in carrot juice
Lactic acid decreases Fe (II) and Fe (III) retention but increases Fe (III) transepithelial transfer by Caco-2 cells
Digestion of barley malt porridges in a gastrointestinal model: Iron dialysability, iron uptake by Caco-2 cells and degradation of beta-glucan
The usefulness of in vitro models to predict the bioavailability of iron and zinc: A consensus statement from the HarvestPlus Expert Consultation
Methods and Options for in vitro Dialyzability; Benefits and Limitations
Improved iron solubility in carrot juice fermented by homo- and hetero-fermentative lactic acid bacteria
Degradation of phytate by High-Phytase Saccharomyces cerevisiae Strains during simulated gastrointestinal digestion
Fish and Cardiovascular Health
Metabolism of extracellular inositol hexaphosphate (phytate) by Saccharomyces cerevisiae
Improved iron solubility in carrot juice fermented by homo- and heterofermentative lactic acid bacteria
Phytate content is reduced and betaglucanase activity suppressed in malted barley steeped with lactic acid at high temperature
Prolonged transit time through the stomach and small intestine improves iron dialyzability and uptake in vitro
Combined Impact of pH and Organic Acids on Iron Uptake by Caco-2 Cells
Hydrothermal treatment and malting of barley improved zinc absorption but not calcium absorption in humans
Effects of malting on betaglucanase and phytase activity in barley grain
In vitro and in vivo degradation of phytate
Phytogenic and microbial phytases in human nutrition
Bioavailability of minerals in legumes
Organic acids influence iron uptake in the human epithelial cell line Caco-2
Methods for analysis of phytate
Extrinsic labeling of zinc and calcium in bread
Phytate degradation by micro-organisms in synthetic media and pea flour
Functional Foods - Är maten genvägen till hälsa?
Simultaneous and sensitive analysis of Cu, Ni, Zn, Co, Mn, and Fe in food and biological samples by ion chromatography
Food for helath; an insight into the natural bioactive compounds of plants
Development of predictive models for optimization of phytate degradation in wheat and rye during hydrothermal processing
Rapid analyzes of inositol phosphates
Production process for high-quality pea-protein isolate with low content of oligosaccharides and phytate
Phytate content and phytate degradation by endogenous phytase in pea (Pisum sativum)
Determination of the retention of 47Ca by whole-body counting
Optimal conditions for phytate degradation, estimation of phytase activity, and localization of phytate in barley (Cv. Blenheim)
Determination of the retention of 47Ca by whole-body counting
Developing functional ingredients. A case study
9. IP6 hydrolysis by Baker’s yeast: Capacity, kinetics and degradation products
Functional foods. Är maten genvägen til hälsa?
The influence of pH and temperature on endogenous phytase activity and on hydrolysis of inositol hexa phosphate in lentil, faba bean and pea seeds.
Processing of quinoa (Chenopedium quinoa, Willd): Effect on the in vitro iron availability and phytate hydrolysis
Inositol phosphates influence iron uptake in Caco-2 cells
Hydrothermal processing of barley (cv. Blenheim).Optimization of phytate degradation and increase of free myo-inositol.
Effect of pretreatment of feed on availability of specific elements in pigs.
Processing of quinoa(Chenopodium Quinoa): effects on in vitro iron availability and phytate hydrolysis.
Inositol phosphates with different numbers of phosphate groups influence iron absorption in humans
. Binding of Cu2+, Zn2+, and Cd2+ to inositol tri-, tetra-, penta-, and hexaphosphates.
Phytate hydrolysis in pigs fed a barley-rapeseed meal diet treated with Aspergillus niger phytase or steeped with whey.
High-performance chromatografic separation of inositol phosphate isomers on strong anion exchange columns.
Comparison between steeping and pelleting a mixed diet at different calcium levels on phytate degradation in pigs.
Optimization of temperature, time and lactic acid concentration to inactivate lipoxygenase and preserve phytase activity in barley (cv. Blenheim) during soaking.
Phytate reduction in whole grains of wheat, rye, barley and oats during hydrothermal treatment
Determination of isomers of inositol mono- to hexaphosphates in foods and intestinal contents using high performance ion chromatography
Analysis of inositol mono- and diphosphate isomers using high-performance ion chromatography and pulsed amperometric detection.
Dietary Aspergillus niger phytase increases iron absorption i humans
Improved zinc and iron absorption from malted oats with reduced phytate content
Reduction in the levels of phytate during whole meal bread making; effect of yeast and wheat phytases.
Substrates available for colonic fermentation from oat, barley and wheat diets. A study on ileostomy subjects.
Mixed-linked β-glucan from breads of different cereals is degraded in the human ileostomy model.
Malting of oats in a pilot plant process.Effects of heat treatment, storage and soaking conditions on phytate reduction
Iron deficiency among pregnant Pakistanis in Norway and the content of phytic acid in their diet
Degradation of phytic acid by using varied sources of phytases in an oat-based nutritive solution fermented by Lactobacillus Plantarum Strain 299 V
The effect of milk and fermented milk on iron absorption and iron status in ileostomy subjects
Oat β-glucan increases bile acid excretion and a fiber-rich barley fraction increases cholesterol excretion in ileostomy subjects.
Phytate reduction in brown beans (Phaseolus vulgaris L.)
Effects of low-fat milk and fermented low-fat milk on cholesterol absorption and excretion in ileostomy subjects
Alginate, small bowel sterol excretion and absorption of nutrients in ileostomy subjects
High dietary calcium level decreases colonic phytate degradation in pigs fed a rapeseed diet
Lactic fermentation of non-tannin and high-tannin cereals: Effects on in vitro estimation of iron availability and phytate hydrolysis
Determination of oligosaccharides in foods, diets and intestinal contents by high-temperature GC and GC/MS
Phytate hydrolysis during bread-making: Effect of phytase addition
Fermented or fresh vegetables decrease the post-prandial blood glucose and insulin levels in healthy persons
Phytate reduction in oats during malting
Human iron absorption from bread: Inhibiting effects of cereal fiber, phytate and inositol phosphates with different numbers of phosphate groups
Inhibitory effects of isolated inositol phosphates on zinc absorption in humans
Phytate hydrolysis by phytase in cereals. Effects on in vitro estimation of iron availability
Phytate reduction in bread containing oat flour, oat bran or rye bran
A small dose of soluble alginate-fiber affects postprandial glycemia and gastric emptying in humans with diabetes
Calcium: Effect of different amounts on nonheme and heme iron absorption in humans
The effect of food processing on phytate hydrolysis and availability of iron and zinc
Inhibitory effects of phytic acid and other inositol phosphates on zinc and calcium absorption in suckling rats
Effects of inositol tri-, tetra-, penta- and hexaphosphates on in vitro estimation of iron availability
The effect of extrusion cooking of a high fibre cereal product on the absorption of zinc in man
The effect of dietary phytase on the digestion of phytate in the stomach and small intestine of humans
Degradation products of bran phytate formed during digestion in the human small intestine. Effect of extrusion cooking on digestibility
Effect of wheat bran and pectin on bile salt excretion in ileostomy patients
Apparent small intestinal absorption of nitrogen and minerals from soy and meat protein based diets
Extrusion cooking of a high fibre cereal product: II, Effects on apparent absorption of zinc, iron, calcium, magnesium and phosphorus in humans
Extrusion cooking of a high-fibre cereal product. 1. Effects on digestibility and absorption of protein, fat, starch, dietary fibre and phytate in the small intestine
HPLC method for determination of inositol, tri-, tetra-, penta- and hexaphosphates in foods and intestinal contents
Dietary fibre - Determination and physiological effects. A study on ileostomy patients
The effect of citrus pectin on the absorption of nutrients in the small intestine
The effect of wheat bran on the absorption of minerals in the small intestine
Experimental model for in vivo determination of dietary fibre and its effect on the absorption of nutrients in the small intestine
Analytical problems in the determination of dietary fibre.
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Showing 16 research projects
The protein shift - a risk for women and children?
Näringsvärde i växtbaserade köttersättningsprodukter på den svenska marknaden. Analys av protein-, fettkvalitet och biotillgänglighet av mineraler
Mammans mat under graviditet och amning och allergi hos barnet
Förstudie om hållbar och hälsosam proteinförsörjning i Västra Götaland
The role of prenatal diet- and microbiome- derived metabolome in childhood allergy development. Metabolic fingerprinting for allergy prediction
Can the low content of iodine and selenium in vegetarian and vegan food adversely affect thyroid function in pregnant women and impair development of their children?
A limited amount of fluoride promotes early-life dental health but may adversely affect child development
Ett systemtoxikologibaserat angreppssätt för bedömning av kombinationseffekter av toxiska metaller tidigt i livet
Ett nytt sätt att motverka järnbrist: Bioberikning av bröd med hjälp av jäst som producerar hemoglobin
Nutrition i tidig ålder och immunologisk mognad med fokus på förebyggande av allergi
The molecular Fe and Zn speciation in cereal based diets: Unravelling the Chemistry controlling human bioavailability of essential trace elements
Early life nutrition and immune development with focus on allergy prevention
New strategy for developing safe foods for celiac patients. Preventing recognition of gluten by tissue transglutaminase through chemical modification of key binding sites
Designing novel marine food products for healthy ageing