The development of a novel ferric phytate compound for iron fortification of bouillons (part I)
Journal article, 2020

In a series of two studies, we report the development (this study) and evaluation (part II) of a novel ferric phytate compound designed as a condiment iron fortificant. Condiments are used as iron fortification vehicles to reduce the prevalence  of iron deficiency. The challenge for iron fortificants in e.g. a bouillon matrix is to avoid undesired sensory effects and to ensure a reasonable cost. We added phytic acid to chelate iron, and hydrolysed protein to counteract the inhibiting effect of phytic acid on iron bioaccessibility. We characterised four novel ferric phytate compounds, destabilised by hydrolysed plant protein or amino acids. Colour stability of fortified bouillons with ferric phytate compounds was superior to bouillons fortified with ferrous sulfate. The iron-phytate-hydrolysed corn protein compound (Fe-PAHCP) resulted in highest cellular ferritin induction in Caco-2 cells, in both vegetable (36.1 ± 13.40 ng/mg protein) and chicken (73.9 ± 19.93 ng/mg protein) bouillon matrices as observed in the human Caco-2/ HepG2 cell model. Iron uptake (as estimated by ferritin production) from the Fe-PA-HCP compound was about 55% (chicken bouillon) and 66% (vegetable bouillon) of the iron uptake from ferrous sulfate. Based on this study, the Fe-PA-HCP compound was chosen for further evaluation (part II).


Iron bioavailability

Biological Availability


Swarnim Gupta

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Edwin Habeych

Nestlé Research Center

Nathalie Scheers

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Sylvie Merinat

Nestlé Research Center

Birgitte Rey

Nestlé Research Center

Nicola Galaffu

Nestlé Research Center

Ann-Sofie Sandberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Scientific Reports

2045-2322 (ISSN)

Vol. 10 1 5340

Ett nytt sätt att motverka järnbrist: Bioberikning av bröd med hjälp av jäst som producerar hemoglobin

Formas (942-2015-1516), 2016-01-01 -- 2019-12-31.

Driving Forces

Sustainable development

Subject Categories

Cell and Molecular Biology

Forest Science

Other Basic Medicine

Areas of Advance

Health Engineering

Life Science Engineering (2010-2018)





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5/3/2023 8