Differences between Arterial and Venous Umbilical Cord Plasma Metabolome and Association with Parity
Journal article, 2022

Umbilical cord blood is frequently used in health monitoring of the neonate. Results may be affected by the proportion of arterial and venous cord blood, the venous blood coming from the mother to supply oxygen and nutrients to the infant, and the arterial carrying waste products from the fetus. Here, we sampled arterial and venous umbilical cords separately from 48 newly delivered infants and examined plasma metabolomes using GC-MS/MS metabolomics. We investigated differences in metabolomes between arterial and venous blood and their associations with gestational length, birth weight, sex, and whether the baby was the first born or not, as well as maternal age and BMI. Using multilevel random forest analysis, a classification rate of 79% was achieved for arteriovenous differences (p = 0.004). Several monosaccharides had higher concentrations in the arterial cord plasma while amino acids were higher in venous plasma, suggesting that the main differences in the measured arterial and venous plasma metabolomes are related to amino acid and energy metabolism. Venous cord plasma metabolites related to energy metabolism were positively associated with parity (77% classification rate, p = 0.004) while arterial cord plasma metabolites were not. This underlines the importance of defining cord blood type for metabolomic studies.

Metabolomics

Venous

Parity

Arte-rial

Cord

Plasma

Umbilical

Amino acid

Metabolism

Energy

Author

Olle Hartvigsson

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Malin Barman

Karolinska Institutet

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Otto Savolainen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Alastair Ross

AgResearch Lincoln

Anna Sandin

Umeå University

Bo Jacobsson

University of Gothenburg

Sahlgrenska University Hospital

Agnes E Wold

University of Gothenburg

Ann-Sofie Sandberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Carl Brunius

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Metabolites

2218-1989 (ISSN) 22181989 (eISSN)

Vol. 12 2 175

Subject Categories

Pediatrics

Other Clinical Medicine

Nutrition and Dietetics

Infrastructure

Chalmers Infrastructure for Mass spectrometry

DOI

10.3390/metabo12020175

PubMed

35208249

More information

Latest update

12/15/2022