Differences between Arterial and Venous Umbilical Cord Plasma Metabolome and Association with Parity
Artikel i vetenskaplig tidskrift, 2022

Umbilical cord blood is frequently used in health monitoring of the neonate. Results may be affected by the proportion of arterial and venous cord blood, the venous blood coming from the mother to supply oxygen and nutrients to the infant, and the arterial carrying waste products from the fetus. Here, we sampled arterial and venous umbilical cords separately from 48 newly delivered infants and examined plasma metabolomes using GC-MS/MS metabolomics. We investigated differences in metabolomes between arterial and venous blood and their associations with gestational length, birth weight, sex, and whether the baby was the first born or not, as well as maternal age and BMI. Using multilevel random forest analysis, a classification rate of 79% was achieved for arteriovenous differences (p = 0.004). Several monosaccharides had higher concentrations in the arterial cord plasma while amino acids were higher in venous plasma, suggesting that the main differences in the measured arterial and venous plasma metabolomes are related to amino acid and energy metabolism. Venous cord plasma metabolites related to energy metabolism were positively associated with parity (77% classification rate, p = 0.004) while arterial cord plasma metabolites were not. This underlines the importance of defining cord blood type for metabolomic studies.

Arte-rial

Plasma

Energy

Umbilical

Metabolism

Amino acid

Venous

Parity

Metabolomics

Cord

Författare

Olle Hartvigsson

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Malin Barman

Karolinska Institutet

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Otto Savolainen

Chalmers, Biologi och bioteknik, Systembiologi, CMSI

Alastair Ross

AgResearch

Anna Sandin

Umeå universitet

Bo Jacobsson

Göteborgs universitet

Sahlgrenska universitetssjukhuset

Agnes E Wold

Göteborgs universitet

Ann-Sofie Sandberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Carl Brunius

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Metabolites

2218-1989 (ISSN)

Vol. 12 2 175

Ämneskategorier

Pediatrik

Annan klinisk medicin

Näringslära

DOI

10.3390/metabo12020175

PubMed

35208249

Mer information

Senast uppdaterat

2022-02-25