Otto Savolainen

Research Specialist at Systems and Synthetic Biology
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Showing 49 publications

2024

Exposure of Colon-Derived Epithelial Monolayers to Fecal Luminal Factors from Patients with Colon Cancer and Ulcerative Colitis Results in Distinct Gene Expression Patterns

Maria K. Magnusson, Anna Bas Forsberg, Alexandra Verveda et al
International Journal of Molecular Sciences. Vol. 25 (18)
Journal article
2024

AutonoMS: Automated Ion Mobility Metabolomic Fingerprinting

Gabriel Reder, Erik Bjurström, Daniel Brunnsåker et al
Journal of the American Society for Mass Spectrometry. Vol. 35 (3), p. 542-550
Journal article
2024

Fecal Supernatants from Patients with Crohn’s Disease Induce Inflammatory Alterations in M2 Macrophages and Fibroblasts

Frida Gorreja, Mia Bendix, Stephen T.A. Rush et al
Cells. Vol. 13 (1)
Journal article
2024

Identifying metabotypes of insulin resistance severity in children with metabolic syndrome

Álvaro González-Domínguez, Jesús Domínguez-Riscart, Otto Savolainen et al
Cardiovascular Diabetology. Vol. 23 (1)
Journal article
2024

Correlates of Plasma Citrulline, a Potential Marker of Enterocyte Mass, among Children with Stunting: A Cross-Sectional Study in Uganda

Hannah Pesu, Joseph Mbabazi, Rolland Mutumba et al
Journal of Nutrition. Vol. 154 (2), p. 765-776
Journal article
2024

De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast

Xiang Jiao, Xiaozhi Fu, Qishuang Li et al
Nature Communications. Vol. 15, p. 8759-
Journal article
2024

Temporal stability of fecal metabolomic profiles in irritable bowel syndrome

Cristina Iribarren, Otto Savolainen, Maria Sapnara et al
Neurogastroenterology and Motility. Vol. 36 (3)
Journal article
2024

Dietary biomarkers-an update on their validity and applicability in epidemiological studies

Rikard Landberg, Prasoona Karra, Rachel Hoobler et al
Nutrition Reviews. Vol. 82 (9), p. 1260-1280
Review article
2023

High-throughput metabolomics for the design and validation of a diauxic shift model

Daniel Brunnsåker, Gabriel Reder, Nikulkumar Soni et al
NPJ systems biology and applications. Vol. 9 (1), p. 11-
Journal article
2023

Metabolic profiles reflect weight loss maintenance and the composition of diet after very-low-energy diet

Mari Näätänen, A. Kårlund, Santtu Mikkonen et al
Clinical Nutrition. Vol. 42 (7), p. 1126-1141
Journal article
2023

Untargeted Metabolomics Based on Liquid Chromatography-Mass Spectrometry for the Analysis of Plasma and Erythrocyte Samples in Childhood Obesity

Álvaro González-Domínguez, Marina Armeni, Otto Savolainen et al
Methods in Molecular Biology. Vol. 2571, p. 115-122
Book chapter
2022

Differences in Metabolite Composition of Aloe barbadensis Mill. Extracts Lead to Differential Effects on Human Blood T Cell Activity In Vitro

Bani Ahluwalia, Maria K. Magnusson, Fredrik Larsson et al
Molecules. Vol. 27 (19)
Journal article
2022

Metabolomic profiles of mid-trimester amniotic fluid are not associated with subsequent spontaneous preterm delivery or gestational duration at delivery

Maria Hallingstrom, Malin Barman, Otto Savolainen et al
Journal of Maternal-Fetal and Neonatal Medicine. Vol. 35 (11), p. 2054-2062
Journal article
2022

Metabolite Pattern Derived from Lactiplantibacillus plantarum-Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth

Ville M. Koistinen, Maria Hedberg, Lin Shi et al
Molecular Nutrition and Food Research. Vol. 66 (21)
Journal article
2022

Differences between Arterial and Venous Umbilical Cord Plasma Metabolome and Association with Parity

Olle Hartvigsson, Malin Barman, Otto Savolainen et al
Metabolites. Vol. 12 (2)
Journal article
2022

Fecal luminal factors from patients with irritable bowel syndrome induce distinct gene expression of colonoids

Cristina Iribarren, Sofia Nordlander, Johanna Sundin et al
Neurogastroenterology and Motility. Vol. 34 (10)
Journal article
2022

Fecal Luminal Factors from Patients with Gastrointestinal Diseases Alter Gene Expression Profiles in Caco-2 Cells and Colonoids

Luiza Moraes Holst, Cristina Iribarren, Maria Sapnara et al
International Journal of Molecular Sciences. Vol. 23 (24)
Journal article
2022

LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

Justiina Ronkainen, Rozenn Nedelec, Angelica Atehortua et al
Environmental Epidemiology. Vol. 6 (1)
Journal article
2021

Porphyromonas gingivalis Produce Neutrophil Specific Chemoattractants Including Short Chain Fatty Acids

Agnes Dahlstrand Rudin, Arsham Khamzeh, Vignesh Venkatakrishnan et al
Frontiers in cellular and infection microbiology. Vol. 10
Journal article
2021

A polysaccharide utilization locus from the gut bacterium dysgonomonas mossii encodes functionally distinct carbohydrate esterases

Cathleen Kmezik, Scott Mazurkewich, Tomke Meents et al
Journal of Biological Chemistry. Vol. 296
Journal article
2021

De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories

Quanli Liu, Yi Liu, Gang Li et al
Nature Communications. Vol. 12 (1)
Journal article
2021

A Distinct Faecal Microbiota and Metabolite Profile Linked to Bowel Habits in Patients with Irritable Bowel Syndrome

Bani Ahluwalia, Cristina Iribarren, Maria K. Magnusson et al
Cells. Vol. 10 (6)
Journal article
2021

Expanding functional protein sequence spaces using generative adversarial networks

Donatas Repecka, Vykintas Jauniskis, Laurynas Karpus et al
Nature Machine Intelligence. Vol. 3 (4), p. 324-333
Journal article
2021

Impaired Luminal Control of Intestinal Macrophage Maturation in Patients With Ulcerative Colitis During Remission

Lujain Maasfeh, Anetta Härtlova, Stefan Isaksson et al
CMGH Cellular and Molecular Gastroenterology and Hepatology. Vol. 12 (4), p. 1415-1432
Journal article
2020

Community-Based Study of Celiac Disease Autoimmunity Progression in Adults

Rok Seon Choung, Shahryar Khaleghi, Amanda K. Cartee et al
Gastroenterology. Vol. 158 (1), p. 151-159
Journal article
2020

Randomized clinical trial: Effects of Aloe barbadensis Mill. extract on symptoms, fecal microbiota and fecal metabolite profiles in patients with irritable bowel syndrome

Bani Ahluwalia, Maria K. Magnusson, Lena Bohn et al
Neurogastroenterology and Motility. Vol. 32 (8)
Journal article
2020

Effects of a Vegetarian Diet on Cardiometabolic Risk Factors, Gut Microbiota, and Plasma Metabolome in Subjects With Ischemic Heart Disease: A Randomized, Crossover Study

Demir Djekic, Lin Shi, Harald Brolin et al
Journal of the American Heart Association. Vol. 9 (18), p. e016518-e016518
Journal article
2018

Extracts of Equisetum giganteum L and Copaifera reticulate Ducke show strong antiviral activity against the sexually transmitted pathogen herpes simplex virus type 2

M. P. Churqui, L. Lind, Karolina Thörn et al
Journal of Ethnopharmacology. Vol. 210, p. 192-197
Journal article
2018

Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics

Ville Mikael Koistinen, Andreia Bento da Silva, László Abrankó et al
Metabolites. Vol. 8 (3)
Journal article
2017

Quantification of benzoxazinoids and their metabolites in Nordic breads

Katharina Dihm, Mads Vendelbo Lind, Henrik Sundén et al
Food Chemistry. Vol. 235, p. 7-13
Journal article
2017

Coordination of Trivalent Lanthanides with Bismalonamide Ligands: Implications for Liquid-Liquid Extraction

Mikhail S Tyumentsev, Mark Foreman, A. M. Z. Slawin et al
European Journal of Inorganic Chemistry. Vol. 2017 (37), p. 4285-4298
Journal article
2017

Identification and quantification of even and odd chained 5-n alkylresorcinols, branched chain-alkylresorcinols and methylalkylresorcinols in Quinoa (Chenopodium quinoa)

Alastair Ross, Cecilia Svelander, B Göran Karlsson et al
Food Chemistry. Vol. 220, p. 344-351
Journal article
2017

Dietary Protein Sources Beyond Proteins and Amino Acids - A Comparative Study of the Small Molecular Weight Components of Meat and Fish using Metabolomics

Alastair Ross, ANDREW VINCENT, Otto Savolainen et al
FASEB Journal. Vol. 31 (suppl 1), p. abstr. 652.13-
Magazine article
2017

Biomarkers for predicting type 2 diabetes development-Can metabolomics improve on existing biomarkers?

Otto Savolainen, Björn Fagerberg, Mads Vendelbo Lind et al
PLoS ONE. Vol. 12 (7), p. e0177738-
Journal article
2017

Biomarkers of food intake and nutrient status are associated with glucose tolerance status and development of type 2 diabetes in older Swedish women

Otto Savolainen, Mads Vendelbo Lind, Göran Bergström et al
American Journal of Clinical Nutrition. Vol. 106 (5), p. 1302-1310
Journal article
2017

Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women.

ANDREW VINCENT, Otto Savolainen, Partho Sen et al
Molecular Nutrition and Food Research. Vol. 61 (3), p. Art no UNSP 1600400-
Journal article
2017

Biomarkers of food intake and nutrient status are associated with glucose tolerance status and development of Type 2 diabetes

Otto Savolainen, Mads Vendelbo Lind, Göran Bergström et al
The FASEB Journal. Vol. 31 (S1), p. 655.4-
Other conference contribution
2017

Splenic Immune Response Is Down-Regulated in C57BL/6J Mice Fed Eicosapentaenoic Acid and Docosahexaenoic Acid Enriched High Fat Diet

Nikulkumar Soni, Alastair Ross, Nathalie Scheers et al
Nutrients. Vol. 9 (1), p. 50-
Journal article
2016

Eicosapentaenoic and Docosahexaenoic Acid-Enriched High Fat Diet Delays Skeletal Muscle Degradation in Mice

Nikulkumar Soni, Alastair Ross, Nathalie Scheers et al
Nutrients. Vol. 8 (9), p. 543-
Journal article
2016

The use of mass spectrometry for analysing metabolite biomarkers in epidemiology: methodological and statistical considerations for application to large numbers of biological samples

Mads Vendelbo Lind, Otto Savolainen, Alastair Ross
European Journal of Epidemiology. Vol. 31 (8), p. 717-733
Review article
2016

A high-throughput method for liquid chromatography-tandem mass spectrometry determination of plasma alkylresorcinols, biomarkers of whole grain wheat and rye intake.

Alastair Ross, Cecilia Svelander, Otto Savolainen et al
Analytical Biochemistry. Vol. 499, p. 1-7
Journal article
2016

A Simultaneous Metabolic Profiling and Quantitative Multimetabolite Metabolomic Method for Human Plasma Using Gas-Chromatography Tandem Mass Spectrometry.

Otto Savolainen, Ann-Sofie Sandberg, Alastair Ross
Journal of Proteome Research. Vol. 15 (1), p. 259-265
Journal article
2015

Glycosylated Benzoxazinoids Are Degraded during Fermentation of Wheat Bran

Otto Savolainen, J. Pekkinen, K. Katina et al
Journal of Agricultural and Food Chemistry. Vol. 63 (25), p. 5943-5949
Journal article
2014

A new biomarker for quinoa intake

Alastair Ross, Otto Savolainen
FASEB Journal. Vol. 28 (1)
Magazine article
2014

The role of oxygen in the liquid fermentation of wheat bran

Otto Savolainen, R. Coda, K. Suomi et al
Food Chemistry. Vol. 153, p. 424-431
Journal article

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Showing 3 research projects

2021–2023

BioMS – a distributed national infrastructure in biological mass spectrometry

Otto Savolainen CMSI
Swedish Research Council (VR)

2021–

SciLifeLab Metabolomics platform

Otto Savolainen CMSI
Rikard Landberg Food and Nutrition Science
Carl Brunius Food and Nutrition Science
Science for Life Laboratory (SciLifeLab)

2019–2021

Dietary biomarkers 2.0: from potential towards implementation

Otto Savolainen CMSI
Alastair Ross Food and Nutrition Science
Rikard Landberg Food and Nutrition Science
Formas

1 publication exists
There might be more projects where Otto Savolainen participates, but you have to be logged in as a Chalmers employee to see them.