Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics
Journal article, 2018

Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-art analytical methodologies, including untargeted metabolomics based on high-resolution mass spectrometry, are required for the profiling of these compounds in complex matrices, including plant food materials and biofluids. The aim of this project was to compare the analytical coverage of untargeted metabolomics methods independently developed and employed in various European platforms. In total, 56 chemical standards representing the most common classes of bioactive compounds spread over a wide chemical space were selected and analyzed by the participating platforms (n = 13) using their preferred untargeted method. The results were used to define analytical criteria for a successful analysis of plant food bioactives. Furthermore, they will serve as a basis for an optimized consensus method.

Phytochemicals

Mass spectrometry

Method development

Author

Ville Mikael Koistinen

University of Eastern Finland

Andreia Bento da Silva

Nova University of Lisbon

László Abrankó

Szent István University

Dorrain Low

Clermont Auvergne University

Rocio Garcia Villalba

CEBAS- CSIC, Centro de Edafología y Biología Aplicada del Segura

Francisco Tomás Barberán

CEBAS- CSIC, Centro de Edafología y Biología Aplicada del Segura

Rikard Landberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Otto Savolainen

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Inmaculada Alvarez-Acero

CSIC - Instituto de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN)

Sonia de Pascual-Teresa

CSIC - Instituto de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN)

Christof Van Poucke

Flanders Research Institute for Agriculture Fisheries and Food (ILVO),

Conceição Almeida

Nova University of Lisbon

Lucie Petrásková

Czech Academy of Sciences

Kateřina Valentová

Czech Academy of Sciences

Stephanie Durand

Clermont Auvergne University

Wiesław Wiczkowski

Polish Academy of Sciences

Dorota Szawara-Nowak

Polish Academy of Sciences

Raúl González-Domínguez

University of Barcelona

Technical Research Centre of Finland (VTT)

Institute of Health Carlos III

Rafael Llorach

Institute of Health Carlos III

Technical Research Centre of Finland (VTT)

University of Barcelona

Cristina Andres-Lacueva

Institute of Health Carlos III

Technical Research Centre of Finland (VTT)

University of Barcelona

Anna-Marja Aura

Instituto de Biologia Experimental e Tecnologica

Tuulikki Seppänen-Laakso

Instituto de Biologia Experimental e Tecnologica

K. Hanhineva

University of Eastern Finland

Claudine Manach

Clermont Auvergne University

Maria Rosário Bronze

Nova University of Lisbon

University of Lisbon

Metabolites

2218-1989 (ISSN)

Vol. 8 3 46

Subject Categories

Analytical Chemistry

Food Science

Environmental Sciences

DOI

10.3390/metabo8030046

More information

Latest update

7/8/2021 1