Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics
Artikel i vetenskaplig tidskrift, 2018
Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-art analytical methodologies, including untargeted metabolomics based on high-resolution mass spectrometry, are required for the profiling of these compounds in complex matrices, including plant food materials and biofluids. The aim of this project was to compare the analytical coverage of untargeted metabolomics methods independently developed and employed in various European platforms. In total, 56 chemical standards representing the most common classes of bioactive compounds spread over a wide chemical space were selected and analyzed by the participating platforms (n = 13) using their preferred untargeted method. The results were used to define analytical criteria for a successful analysis of plant food bioactives. Furthermore, they will serve as a basis for an optimized consensus method.
Phytochemicals
Mass spectrometry
Method development
Författare
Ville Mikael Koistinen
Itä-Suomen Yliopisto
Andreia Bento da Silva
Universidade NOVA de Lisboa
László Abrankó
Szent István Egyetem
Dorrain Low
Université Clermont Auvergne
Rocio Garcia Villalba
CEBAS- CSIC, Centro de Edafología y Biología Aplicada del Segura
Francisco Tomás Barberán
CEBAS- CSIC, Centro de Edafología y Biología Aplicada del Segura
Rikard Landberg
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Otto Savolainen
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Inmaculada Alvarez-Acero
CSIC - Instituto de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN)
Sonia de Pascual-Teresa
CSIC - Instituto de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN)
Christof Van Poucke
Instituut voor Landbouw-, Visserij- en Voedingsonderzoek
Conceição Almeida
Universidade NOVA de Lisboa
Lucie Petrásková
Czech Academy of Sciences
Kateřina Valentová
Czech Academy of Sciences
Stephanie Durand
Université Clermont Auvergne
Wiesław Wiczkowski
Polish Academy of Sciences
Dorota Szawara-Nowak
Polish Academy of Sciences
Raúl González-Domínguez
Universitat de Barcelona
Teknologian Tutkimuskeskus (VTT)
Instituto de Salud Carlos III
Rafael Llorach
Instituto de Salud Carlos III
Teknologian Tutkimuskeskus (VTT)
Universitat de Barcelona
Cristina Andres-Lacueva
Instituto de Salud Carlos III
Teknologian Tutkimuskeskus (VTT)
Universitat de Barcelona
Anna-Marja Aura
Instituto de Biologia Experimental e Tecnologica
Tuulikki Seppänen-Laakso
Instituto de Biologia Experimental e Tecnologica
K. Hanhineva
Itä-Suomen Yliopisto
Claudine Manach
Université Clermont Auvergne
Maria Rosário Bronze
Universidade NOVA de Lisboa
Universidade de Lisboa
Metabolites
2218-1989 (ISSN) 22181989 (eISSN)
Vol. 8 3 46Ämneskategorier
Analytisk kemi
Livsmedelsvetenskap
Miljövetenskap
DOI
10.3390/metabo8030046