Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics
Artikel i vetenskaplig tidskrift, 2018
Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-art analytical methodologies, including untargeted metabolomics based on high-resolution mass spectrometry, are required for the profiling of these compounds in complex matrices, including plant food materials and biofluids. The aim of this project was to compare the analytical coverage of untargeted metabolomics methods independently developed and employed in various European platforms. In total, 56 chemical standards representing the most common classes of bioactive compounds spread over a wide chemical space were selected and analyzed by the participating platforms (n = 13) using their preferred untargeted method. The results were used to define analytical criteria for a successful analysis of plant food bioactives. Furthermore, they will serve as a basis for an optimized consensus method.
Method development
Mass spectrometry
Phytochemicals
Författare
Ville Mikael Koistinen
Itä-Suomen Yliopisto
Andreia Bento da Silva
Universidade NOVA de Lisboa
László Abrankó
Szent István Egyetem
Dorrain Low
Université Clermont Auvergne
Rocio Garcia Villalba
Consejo Superior de Investigaciones Científicas (CSIC)
Francisco Tomás Barberán
Consejo Superior de Investigaciones Científicas (CSIC)
Rikard Landberg
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Otto Savolainen
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Inmaculada Alvarez-Acero
Consejo Superior de Investigaciones Científicas (CSIC)
Sonia de Pascual-Teresa
Consejo Superior de Investigaciones Científicas (CSIC)
Christof Van Poucke
Instituut voor Landbouw-, Visserij- en Voedingsonderzoek
Conceição Almeida
Universidade NOVA de Lisboa
Lucie Petrásková
Czech Academy of Sciences
Kateřina Valentová
Czech Academy of Sciences
Stephanie Durand
Université Clermont Auvergne
Wiesław Wiczkowski
Polish Academy of Sciences
Dorota Szawara-Nowak
Polish Academy of Sciences
Raúl González-Domínguez
Universitat de Barcelona
Instituto de Salud Carlos III
Teknologian Tutkimuskeskus (VTT)
Rafael Llorach
Teknologian Tutkimuskeskus (VTT)
Instituto de Salud Carlos III
Universitat de Barcelona
Cristina Andres-Lacueva
Instituto de Salud Carlos III
Universitat de Barcelona
Teknologian Tutkimuskeskus (VTT)
Anna-Marja Aura
Instituto de Biologia Experimental e Tecnologica
Tuulikki Seppänen-Laakso
Instituto de Biologia Experimental e Tecnologica
K. Hanhineva
Itä-Suomen Yliopisto
Claudine Manach
Université Clermont Auvergne
Maria Rosário Bronze
Universidade NOVA de Lisboa
Universidade de Lisboa
Metabolites
2218-1989 (ISSN) 22181989 (eISSN)
Vol. 8 3 46Ämneskategorier (SSIF 2011)
Analytisk kemi
Livsmedelsvetenskap
Miljövetenskap
DOI
10.3390/metabo8030046