Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort).
Journal article, 2015

Exposure to polyunsaturated fatty acids (PUFA) influences immune function and may affect the risk of allergy development. Long chain PUFAs are produced from dietary precursors catalyzed by desaturases and elongases encoded by FADS and ELOVL genes. In 211 subjects, we investigated whether polymorphisms in the FADS gene cluster and the ELOVL2 gene were associated with allergy or PUFA composition in serum phospholipids in a Swedish birth-cohort sampled at birth and at 13 years of age; allergy was diagnosed at 13 years of age. Minor allele carriers of rs102275 and rs174448 (FADS gene cluster) had decreased proportions of 20:4 n-6 in cord and adolescent serum and increased proportions of 20:3 n-6 in cord serum as well as a nominally reduced risk of developing atopic eczema, but not respiratory allergy, at 13 years of age. Minor allele carriers of rs17606561 in the ELOVL2 gene had nominally decreased proportions of 20:4 n-6 in cord serum but ELOVL polymorphisms (rs2236212 and rs17606561) were not associated with allergy development. Thus, reduced capacity to desaturase n-6 PUFAs due to FADS polymorphisms was nominally associated with reduced risk for eczema development, which could indicate a pathogenic role for long-chain PUFAs in allergy development.

elongase

atopic eczema

umbilical cord serum

fatty acid desaturase

single nucleotide polymorphism

allergy

long chain polyunsaturated fatty acids

nutrigenetics

FADS

BAS birth cohort

respiratory allergy

ELOVL2

arachidonic acid

phospholipids

Author

Malin Barman

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Staffan Nilsson

Chalmers, Mathematical Sciences, Mathematical Statistics

University of Gothenburg

Åsa Torinsson Naluai

University of Gothenburg

Anna Sandin

Umeå University

Agnes E Wold

University of Gothenburg

Ann-Sofie Sandberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Nutrients

2072-6643 (ISSN)

Vol. 7 12 10100-10115

Subject Categories

Pediatrics

Clinical Medicine

Analytical Chemistry

Immunology

Immunology in the medical area

Respiratory Medicine and Allergy

Genetics

Areas of Advance

Life Science Engineering (2010-2018)

DOI

10.3390/nu7125521

PubMed

26633493

More information

Latest update

2/27/2018