Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort).
Artikel i vetenskaplig tidskrift, 2015

Exposure to polyunsaturated fatty acids (PUFA) influences immune function and may affect the risk of allergy development. Long chain PUFAs are produced from dietary precursors catalyzed by desaturases and elongases encoded by FADS and ELOVL genes. In 211 subjects, we investigated whether polymorphisms in the FADS gene cluster and the ELOVL2 gene were associated with allergy or PUFA composition in serum phospholipids in a Swedish birth-cohort sampled at birth and at 13 years of age; allergy was diagnosed at 13 years of age. Minor allele carriers of rs102275 and rs174448 (FADS gene cluster) had decreased proportions of 20:4 n-6 in cord and adolescent serum and increased proportions of 20:3 n-6 in cord serum as well as a nominally reduced risk of developing atopic eczema, but not respiratory allergy, at 13 years of age. Minor allele carriers of rs17606561 in the ELOVL2 gene had nominally decreased proportions of 20:4 n-6 in cord serum but ELOVL polymorphisms (rs2236212 and rs17606561) were not associated with allergy development. Thus, reduced capacity to desaturase n-6 PUFAs due to FADS polymorphisms was nominally associated with reduced risk for eczema development, which could indicate a pathogenic role for long-chain PUFAs in allergy development.

elongase

atopic eczema

umbilical cord serum

fatty acid desaturase

single nucleotide polymorphism

allergy

long chain polyunsaturated fatty acids

nutrigenetics

FADS

BAS birth cohort

respiratory allergy

ELOVL2

arachidonic acid

phospholipids

Författare

Malin Barman

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Staffan Nilsson

Chalmers, Matematiska vetenskaper, matematisk statistik

Göteborgs universitet

Åsa Torinsson Naluai

Göteborgs universitet

Anna Sandin

Umeå universitet

Agnes E Wold

Göteborgs universitet

Ann-Sofie Sandberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Nutrients

2072-6643 (ISSN)

Vol. 7 12 10100-10115

Ämneskategorier

Pediatrik

Klinisk medicin

Analytisk kemi

Immunologi

Immunologi inom det medicinska området

Lungmedicin och allergi

Genetik

Styrkeområden

Livsvetenskaper och teknik

DOI

10.3390/nu7125521

PubMed

26633493

Mer information

Senast uppdaterat

2018-02-27