A three-dimensional anisotropic point process characterization for pharmaceutical coatings
Journal article, 2017

© 2017 Elsevier B.V. Spatial characterization and modeling of the structure of a material may provide valuable knowledge on its properties and function. Especially, for a drug formulation coated with a polymer film, understanding the relationship between pore structure and drug release properties is important to optimize the coating film design. Here, we use methods from image analysis and spatial statistics to characterize and model the pore structure in pharmaceutical coatings. More precisely, we use and develop point process theory to characterize the branching structure of a polymer blended film with data from confocal laser scanning microscopy. Point patterns, extracted by identifying branching points of pore channels, are both inhomogeneous and anisotropic. Therefore, we introduce a directional version of the inhomogeneous K-function to study the anisotropy and then suggest two alternative ways to model the anisotropic three-dimensional structure. First, we apply a linear transformation to the data such that it appears isotropic and subsequently fit isotropic inhomogeneous Strauss or Lennard-Jones models to the transformed pattern. Second, we include the anisotropy directly in a Lennard-Jones and a more flexible step-function model with anisotropic pair-potential functions. The methods presented will be useful for anisotropic inhomogeneous point patterns in general and for characterizing porous material in particular.

Porous material

Pairwise Gibbs process

Lennard-Jones pair-potential function

K-function

Inhomogeneity

Author

Henrike Häbel

University of Gothenburg

Chalmers, Mathematical Sciences, Applied Mathematics and Statistics

SuMo Biomaterials

M. Marucci

Catherine Boissier

K. Schladitz

Claudia Redenbach

Aila Särkkä

SuMo Biomaterials

University of Gothenburg

Chalmers, Mathematical Sciences

Spatial Statistics

2211-6753 (ISSN)

Vol. 22 306-320

Subject Categories

Polymer Chemistry

Probability Theory and Statistics

Areas of Advance

Materials Science

DOI

10.1016/j.spasta.2017.05.003

More information

Created

10/10/2017