Tailor-made conductive inks from cellulose nanofibrils for 3D printing of neural guidelines
Journal article, 2018

Neural tissue engineering (TE), an innovative biomedical method of brain study, is very dependent on scaffolds that support cell development into a functional tissue. Recently, 3D patterned scaffolds for neural TE have shown significant positive effects on cells by a more realistic mimicking of actual neural tissue. In this work, we present a conductive nanocellulose-based ink for 3D printing of neural TE scaffolds. It is demonstrated that by using cellulose nanofibrils and carbon nanotubes as ink constituents, it is possible to print guidelines with a diameter below 1 mm and electrical conductivity of 3.8 × 10 −1 S cm −1 . The cell culture studies reveal that neural cells prefer to attach, proliferate, and differentiate on the 3D printed conductive guidelines. To our knowledge, this is the first research effort devoted to using cost-effective cellulosic 3D printed structures in neural TE, and we suppose that much more will arise in the near future.

Conductive ink

Neural tissue engineering

3D printing

Cellulose nanofibrils

Author

Volodymyr Kuzmenko

Chalmers, Microtechnology and Nanoscience (MC2), Electronics Material and Systems Laboratory

Wallenberg Wood Science Center (WWSC)

Erdem Karabulut

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Paul Gatenholm Group

Wallenberg Wood Science Center (WWSC)

Elin Pernevik

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Polymer Technology

Anke Sanz-Velasco

Wallenberg Wood Science Center (WWSC)

Chalmers, Microtechnology and Nanoscience (MC2), Electronics Material and Systems Laboratory

Paul Gatenholm

Wallenberg Wood Science Center (WWSC)

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Paul Gatenholm Group

Carbohydrate Polymers

0144-8617 (ISSN)

Vol. 189 22-30

Subject Categories

Cell Biology

Neurosciences

Cell and Molecular Biology

DOI

10.1016/j.carbpol.2018.01.097

More information

Latest update

4/9/2018 8