Tailor-made conductive inks from cellulose nanofibrils for 3D printing of neural guidelines
Artikel i vetenskaplig tidskrift, 2018

Neural tissue engineering (TE), an innovative biomedical method of brain study, is very dependent on scaffolds that support cell development into a functional tissue. Recently, 3D patterned scaffolds for neural TE have shown significant positive effects on cells by a more realistic mimicking of actual neural tissue. In this work, we present a conductive nanocellulose-based ink for 3D printing of neural TE scaffolds. It is demonstrated that by using cellulose nanofibrils and carbon nanotubes as ink constituents, it is possible to print guidelines with a diameter below 1 mm and electrical conductivity of 3.8 × 10 −1 S cm −1 . The cell culture studies reveal that neural cells prefer to attach, proliferate, and differentiate on the 3D printed conductive guidelines. To our knowledge, this is the first research effort devoted to using cost-effective cellulosic 3D printed structures in neural TE, and we suppose that much more will arise in the near future.

Conductive ink

Neural tissue engineering

3D printing

Cellulose nanofibrils

Författare

Volodymyr Kuzmenko

Chalmers, Mikroteknologi och nanovetenskap (MC2), Elektronikmaterial och system

Wallenberg Wood Science Center (WWSC)

Erdem Karabulut

Paul Gatenholm Group

Wallenberg Wood Science Center (WWSC)

Elin Pernevik

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Polymerteknologi

Anke Sanz-Velasco

Wallenberg Wood Science Center (WWSC)

Chalmers, Mikroteknologi och nanovetenskap (MC2), Elektronikmaterial och system

Paul Gatenholm

Wallenberg Wood Science Center (WWSC)

Paul Gatenholm Group

Carbohydrate Polymers

0144-8617 (ISSN)

Vol. 189 22-30

Ämneskategorier

Cellbiologi

Neurovetenskaper

Cell- och molekylärbiologi

DOI

10.1016/j.carbpol.2018.01.097