One-carbon metabolism markers are associated with cardiometabolic risk factors
Journal article, 2018

Background and aims: Alterations to one-carbon metabolism, especially elevated plasma homocysteine (Hcy), have been suggested to be both a cause and a consequence of the metabolic syndrome (MS). A deeper understanding of the role of other one-carbon metabolites in MS, including s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH), and the methylation capacity index (SAM:SAH ratio) is required. Methods and results: 118 men and women with MS-risk factors were included in this cross-sectional study and cardiometabolic outcomes along with markers of one-carbon metabolism, including fasting plasma SAM, SAH, Hcy and vitamin B12concentrations, were analysed. Multiple linear regression models were also used to examine the association between plasma one-carbon metabolites and cardiometabolic health features. We found that fasting plasma concentrations of Hcy, SAM and SAH were all positively correlated with markers of adiposity, including BMI (increase in BMI per 1-SD increase in one-carbon metabolite: 0.92 kg/m295% CI (0.28; 1.56), p = 0.005; 0.81 (0.15; 1.47), p = 0.02; 0.67 (−0.01; 1.36), p = 0.05, respectively). Hcy, but not SAM, SAH or SAM:SAH ratio was associated with BMI and body fat percentage after mutual adjustments. SAM concentrations were associated with higher fasting insulin (9.5% 95% CI (0.3; 19.5) per SD increase in SAM, p = 0.04), HOMA-IR (10.8% (0.8; 21.9), p = 0.03) and TNF-α (11.8% (5.0; 19.0), p < 0.001). Conclusion: We found little evidence for associations between SAM:SAH ratio and cardiometabolic variables, but higher plasma concentrations of SAM, SAH and Hcy are related to an overall higher risk of metabolic dysfunctions. The studies were registered at (NCT01719913 & NCT01731366).




Insulin resistance

Metabolic syndrome


Mads Vendelbo Lind

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

University of Copenhagen

L. Lauritzen

University of Copenhagen

H. Vestergaard

Steno Diabetes Center

University of Copenhagen

T. Hansen

University of Copenhagen

O. B. Pedersen

University of Copenhagen

M. Kristensen

University of Copenhagen

Alastair Ross

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Nutrition, Metabolism and Cardiovascular Diseases

0939-4753 (ISSN) 1590-3729 (eISSN)

Vol. 28 4 402-410

Subject Categories

Endocrinology and Diabetes

Other Clinical Medicine

Nutrition and Dietetics



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Latest update

7/4/2018 1