Design strategy of a graphene based bio-sensor for glucose
Journal article, 2018

A novel graphene-based glucose sensor-design is formulated and explored in silico. An ad hoc host molecule is tailored to bind to glucose by multiple hydrogen bonds. A pyridinic core is chosen for this receptor in order to allow for “socket-plug” dative bonding to boron sites of boron doped graphene. The modeling employs DFT (Density Functional Theory) together with an effective aqueous environment to take into account the solvation effect. High selectivity is demonstrated for the suggested host molecule towards glucose as compared to other possible competitors in blood such as fructose, biotin and ascorbic acid. A route to achieve improved sensitivity, exploiting the hydrophilic/hydrophobic properties of the host + glucose system for enhanced selective binding to the hydrophobic boron doped graphene support is discussed.

Author

Valentina Cantatore

Chalmers, Chemistry and Chemical Engineering, Energy and Material, Environmental Inorganic Chemistry

University of Milano-Bicocca

Santosh Pandit

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Venkata Raghu Mokkapati

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Severin Schindler

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Siegfried Eigler

Freie Universität Berlin

Ivan Mijakovic

Technical University of Denmark (DTU)

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Itai Panas

Chalmers, Chemistry and Chemical Engineering, Energy and Material, Environmental Inorganic Chemistry 2

Carbon

0008-6223 (ISSN)

Vol. 137 343-348

Subject Categories

Theoretical Chemistry

Organic Chemistry

DOI

10.1016/j.carbon.2018.05.044

More information

Latest update

6/25/2018