Reconfigurable Carbon Nanotube Multiplexed Sensing Devices
Journal article, 2018

Here we report on the fabrication of reconfigurable and solution processable nanoscale biosensors with multisensing capability, based on single-walled carbon nanotubes (SWCNTs). Distinct DNA-wrapped (hence water-soluble) CNTs were immobilized from solution onto different prepatterned electrodes on the same chip, via a low-cost dielectrophoresis (DEP) methodology. The CNTs were functionalized with specific, and different, aptamer sequences that were employed as selective recognition elements for biomarkers indicative of stress and neuro-trauma conditions. Multiplexed detection of three different biomarkers was successfully performed, and real-time detection was achieved in serum down to physiologically relevant concentrations of 50 nM, 10 nM, and 500 pM for cortisol, dehydroepiandrosterone-sulfate (DHEAS), and neuropeptide Y (NPY), respectively. Additionally, the fabricated nanoscale devices were shown to be reconfigurable and reusable via a simple cleaning procedure. The general applicability of the strategy presented, and the facile device fabrication from aqueous solution, hold great potential for the development of the next generation of low power consumption portable diagnostic assays for the simultaneous monitoring of different health parameters.


Xinzhao Xu

Queen Mary University of London

Pierrick Clément

Queen Mary University of London

Johnas Eklöf

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry

Nancy Kelley-Loughnane

Wright-Patterson AFB

Kasper Moth-Poulsen

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry

Jorge L. Chávez

Wright-Patterson AFB

Matteo Palma

Queen Mary University of London

Nano Letters

1530-6984 (ISSN) 1530-6992 (eISSN)

Vol. 18 7 4130-4135

Subject Categories

Analytical Chemistry

Other Chemical Engineering

Other Electrical Engineering, Electronic Engineering, Information Engineering



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