Reconfigurable Carbon Nanotube Multiplexed Sensing Devices
Artikel i vetenskaplig tidskrift, 2018

Here we report on the fabrication of reconfigurable and solution processable nanoscale biosensors with multisensing capability, based on single-walled carbon nanotubes (SWCNTs). Distinct DNA-wrapped (hence water-soluble) CNTs were immobilized from solution onto different prepatterned electrodes on the same chip, via a low-cost dielectrophoresis (DEP) methodology. The CNTs were functionalized with specific, and different, aptamer sequences that were employed as selective recognition elements for biomarkers indicative of stress and neuro-trauma conditions. Multiplexed detection of three different biomarkers was successfully performed, and real-time detection was achieved in serum down to physiologically relevant concentrations of 50 nM, 10 nM, and 500 pM for cortisol, dehydroepiandrosterone-sulfate (DHEAS), and neuropeptide Y (NPY), respectively. Additionally, the fabricated nanoscale devices were shown to be reconfigurable and reusable via a simple cleaning procedure. The general applicability of the strategy presented, and the facile device fabrication from aqueous solution, hold great potential for the development of the next generation of low power consumption portable diagnostic assays for the simultaneous monitoring of different health parameters.

Författare

Xinzhao Xu

Queen Mary University of London

Pierrick Clément

Queen Mary University of London

Johnas Eklöf

Kasper Moth-Poulsen Group

Nancy Kelley-Loughnane

Wright-Patterson AFB

Kasper Moth-Poulsen

Kasper Moth-Poulsen Group

Jorge L. Chávez

Wright-Patterson AFB

Matteo Palma

Queen Mary University of London

Nano Letters

1530-6984 (ISSN) 1530-6992 (eISSN)

Vol. 18 7 4130-4135

Ämneskategorier

Analytisk kemi

Annan kemiteknik

Annan elektroteknik och elektronik

DOI

10.1021/acs.nanolett.8b00856

Mer information

Senast uppdaterat

2018-08-17