Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition
Journal article, 2019
The epidemiological evidence regarding the association of coffee and tea consumption with prostate cancer risk is inconclusive, and few cohort studies have assessed these associations by disease stage and grade. We examined the associations of coffee (total, caffeinated and decaffeinated) and tea intake with prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 142,196 men, 7,036 incident prostate cancer cases were diagnosed over 14 years of follow-up. Data on coffee and tea consumption were collected through validated country-specific food questionnaires at baseline. We used Cox proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (CI). Models were stratified by center and age, and adjusted for anthropometric, lifestyle and dietary factors. Median coffee and tea intake were 375 and 106 mL/day, respectively, but large variations existed by country. Comparing the highest (median of 855 mL/day) versus lowest (median of 103 mL/day) consumers of coffee and tea (450 vs. 12 mL/day) the HRs were 1.02 (95% CI, 0.94–1.09) and 0.98 (95% CI, 0.90–1.07) for risk of total prostate cancer and 0.97 (95% CI, 0.79–1.21) and 0.89 (95% CI, 0.70–1.13) for risk of fatal disease, respectively. No evidence of association was seen for consumption of total, caffeinated or decaffeinated coffee or tea and risk of total prostate cancer or cancer by stage, grade or fatality in this large cohort. Further investigations are needed to clarify whether an association exists by different preparations or by concentrations and constituents of these beverages.
decaffeinated
caffeinated
prostate cancer
tea
EPIC
coffee
Author
Abhijit Sen
University of Ioannina
Norwegian University of Science and Technology (NTNU)
Nikos Papadimitriou
University of Ioannina
Pagona Lagiou
University of Athens
Academy of Athens
Harvard School of Public Health
Aurora Perez-Cornago
University of Oxford
Ruth C. Travis
University of Oxford
Timothy J. Key
University of Oxford
Neil Murphy
International Agency for Research on Cancer (IARC)
Marc Gunter
International Agency for Research on Cancer (IARC)
Heinz Freisling
International Agency for Research on Cancer (IARC)
Ioanna Tzoulaki
University of Ioannina
Imperial College London
David C. Muller
Imperial College London
Amanda J. Cross
Imperial College London
David S. Lopez
University of Texas
Manuela Bergmann
German Institute of Human Nutrition
Heiner Boeing
German Institute of Human Nutrition
Christina Bamia
University of Athens
Hellenic Health Foundation, Athens
Anastasia Kotanidou
University of Athens
Hellenic Health Foundation, Athens
Anna Karakatsani
University of Athens
Hellenic Health Foundation, Athens
Anne Tjønneland
Danish Cancer Research Society Center
C. Kyro
Danish Cancer Research Society Center
Malene Outzen
Danish Cancer Research Society Center
María Luisa Redondo
Public Health Directorate
Valerie Cayssials
Bellvitge Biomedical Research Institute IDIBELL
Maria Dolores Chirlaque
Health Council of Murcia
University of Murcia
CIBER in Epidemiology and Public Health (CIBERESP)
Aurelio Barricarte
Navarra Institute for Health Research (IdiSNA)
CIBER in Epidemiology and Public Health (CIBERESP)
Navarra Public Health Institute
Maria Jose Sánchez
CIBER in Epidemiology and Public Health (CIBERESP)
Escuela Andaluza Salud Publica
Nerea Larrañaga
CIBER in Epidemiology and Public Health (CIBERESP)
Public Health Division of Gipuzkoa
Rosario Tumino
Azienda Ospedaliera Civile M.P. Arezzo
Sara Grioni
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Domenico Palli
Centro Per Lo Studio E La Prevenzione Oncologica
Saverio Caini
Centro Per Lo Studio E La Prevenzione Oncologica
Carlotta Sacerdote
Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino
Bas Bueno-de-Mesquita
University of Malaya
Utrecht University
Imperial College London
Netherlands National Institute for Public Health and the Environment
Tilman Kühn
German Cancer Research Center (DKFZ)
Rudolf Kaaks
German Cancer Research Center (DKFZ)
Lena Nilsson
Umeå University
Rikard Landberg
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
Umeå University
Peter Wallström
Lund University
Isabel Drake
Lund University
Bodil Hammer Bech
Aarhus University
K. Overvad
Aarhus University
Dagfinn Aune
Imperial College London
Bjørknes University College
Kay Tee Khaw
University of Cambridge
Elio Riboli
Imperial College London
Dimitrios Trichopoulos
Hellenic Health Foundation, Athens
Harvard School of Public Health
Antonia Trichopoulou
Hellenic Health Foundation, Athens
University of Athens
Konstantinos K. Tsilidis
University of Ioannina
Imperial College London
International Journal of Cancer
0020-7136 (ISSN) 1097-0215 (eISSN)
Vol. 144 2 240-250Subject Categories (SSIF 2011)
Urology and Nephrology
Cancer and Oncology
Nutrition and Dietetics
DOI
10.1002/ijc.31634