Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition
Journal article, 2019

The epidemiological evidence regarding the association of coffee and tea consumption with prostate cancer risk is inconclusive, and few cohort studies have assessed these associations by disease stage and grade. We examined the associations of coffee (total, caffeinated and decaffeinated) and tea intake with prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 142,196 men, 7,036 incident prostate cancer cases were diagnosed over 14 years of follow-up. Data on coffee and tea consumption were collected through validated country-specific food questionnaires at baseline. We used Cox proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (CI). Models were stratified by center and age, and adjusted for anthropometric, lifestyle and dietary factors. Median coffee and tea intake were 375 and 106 mL/day, respectively, but large variations existed by country. Comparing the highest (median of 855 mL/day) versus lowest (median of 103 mL/day) consumers of coffee and tea (450 vs. 12 mL/day) the HRs were 1.02 (95% CI, 0.94–1.09) and 0.98 (95% CI, 0.90–1.07) for risk of total prostate cancer and 0.97 (95% CI, 0.79–1.21) and 0.89 (95% CI, 0.70–1.13) for risk of fatal disease, respectively. No evidence of association was seen for consumption of total, caffeinated or decaffeinated coffee or tea and risk of total prostate cancer or cancer by stage, grade or fatality in this large cohort. Further investigations are needed to clarify whether an association exists by different preparations or by concentrations and constituents of these beverages.

decaffeinated

caffeinated

tea

prostate cancer

EPIC

coffee

Author

Abhijit Sen

Norwegian University of Science and Technology (NTNU)

University of Ioannina

Nikos Papadimitriou

University of Ioannina

Pagona Lagiou

Harvard School of Public Health

University of Athens

Academy of Athens

Aurora Perez-Cornago

University of Oxford

Ruth C. Travis

University of Oxford

Timothy J. Key

University of Oxford

Neil Murphy

International Agency for Research on Cancer (IARC)

Marc Gunter

International Agency for Research on Cancer (IARC)

Heinz Freisling

International Agency for Research on Cancer (IARC)

Ioanna Tzoulaki

Imperial College London

University of Ioannina

David C. Muller

Imperial College London

Amanda J. Cross

Imperial College London

David S. Lopez

University of Texas Medical School

University of Texas

Manuela Bergmann

German Institute of Human Nutrition

Heiner Boeing

German Institute of Human Nutrition

Christina Bamia

Hellenic Health Foundation, Athens

University of Athens

Anastasia Kotanidou

University of Athens

Hellenic Health Foundation, Athens

Anna Karakatsani

University of Athens

Hellenic Health Foundation, Athens

Anne Tjønneland

Danish Cancer Research Society Center

C. Kyro

Danish Cancer Research Society Center

Malene Outzen

Danish Cancer Research Society Center

María Luisa Redondo

Public Health Directorate

Valerie Cayssials

Institut d'Investigació Biomedica de Bellvitge

Maria Dolores Chirlaque

CIBER in Epidemiology and Public Health (CIBERESP)

University of Murcia

Health Council of Murcia

Aurelio Barricarte

Navarra Public Health Institute

CIBER in Epidemiology and Public Health (CIBERESP)

Navarra Institute for Health Research (IdiSNA)

Maria Jose Sánchez

CIBER in Epidemiology and Public Health (CIBERESP)

Escuela Andaluza Salud Publica

Nerea Larrañaga

CIBER in Epidemiology and Public Health (CIBERESP)

Public Health Division of Gipuzkoa

Rosario Tumino

Azienda Ospedaliera Civile M.P. Arezzo

Sara Grioni

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

Domenico Palli

Centro Per Lo Studio E La Prevenzione Oncologica

Saverio Caini

Centro Per Lo Studio E La Prevenzione Oncologica

Carlotta Sacerdote

Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino

Bas Bueno-de-Mesquita

University Medical Center Utrecht

Netherlands National Institute for Public Health and the Environment

Imperial College London

University of Malaya

Tilman Kühn

German Cancer Research Center (DKFZ)

Rudolf Kaaks

German Cancer Research Center (DKFZ)

Lena Nilsson

Umeå University

Rikard Landberg

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Umeå University

Peter Wallström

Lund University

Isabel Drake

Lund University

Bodil Hammer Bech

Aarhus University

K. Overvad

Aarhus University

Dagfinn Aune

Imperial College London

Bjørknes University College

Kay Tee Khaw

University of Cambridge

Elio Riboli

Imperial College London

Dimitrios Trichopoulos

Hellenic Health Foundation, Athens

Harvard School of Public Health

Antonia Trichopoulou

University of Athens

Hellenic Health Foundation, Athens

Konstantinos K. Tsilidis

Imperial College London

University of Ioannina

International Journal of Cancer

0020-7136 (ISSN) 1097-0215 (eISSN)

Vol. 144 2 240-250

Subject Categories

Urology and Nephrology

Cancer and Oncology

Nutrition and Dietetics

DOI

10.1002/ijc.31634

More information

Latest update

8/20/2021