Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies
Review article, 2019
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state-of-the-art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful “tips and tricks” along the analytical workflow.
NMR
GC–MS
metabolomics
LC–MS
nutrition
Author
Marynka M. Ulaszewska
Istituto Agrario San Michele all'Adige
Christoph H. Weinert
Max Rubner-Institut, Germany
Alessia Trimigno
University of Bologna
Reto Portmann
Forschungsanstalt Agroscope Changins-Wadenswil
Cristina Andres-Lacueva
University of Barcelona
René Badertscher
Forschungsanstalt Agroscope Changins-Wadenswil
Lorraine Brennan
University College Dublin
Carl Brunius
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
Achim Bub
Max Rubner-Institut, Germany
Francesco Capozzi
University of Bologna
Marta Cialiè Rosso
University of Turin
Chiara E. Cordero
University of Turin
Hannelore Daniel
Technical University of Munich
Stéphanie Durand
Universite d' Auvergne Clermont-FD 1
Bjoern Egert
Max Rubner-Institut, Germany
Paola G. Ferrario
Max Rubner-Institut, Germany
Edith J.M. Feskens
Wageningen University and Research
Pietro Franceschi
Istituto Agrario San Michele all'Adige
Mar Garcia-Aloy
University of Barcelona
Franck Giacomoni
Universite d' Auvergne Clermont-FD 1
Pieter Giesbertz
Technical University of Munich
Raúl González-Domínguez
University of Barcelona
K. Hanhineva
University of Eastern Finland
Lieselot Y. Hemeryck
Ghent university
Joachim Kopka
Max Planck Society
Sabine E. Kulling
Max Rubner-Institut, Germany
Rafael Llorach
University of Barcelona
Claudine Manach
Universite d' Auvergne Clermont-FD 1
Fulvio Mattivi
Istituto Agrario San Michele all'Adige
University of Trento
Carole Migné
Universite d' Auvergne Clermont-FD 1
Linda H. Münger
Forschungsanstalt Agroscope Changins-Wadenswil
Beate Ott
Technical University of Munich
Gianfranco Picone
University of Bologna
Grégory Pimentel
Forschungsanstalt Agroscope Changins-Wadenswil
E. Pujos-Guillot
Universite d' Auvergne Clermont-FD 1
Samantha Riccadonna
Istituto Agrario San Michele all'Adige
Manuela J. Rist
Max Rubner-Institut, Germany
Caroline Rombouts
Ghent university
Josep Rubert
Istituto Agrario San Michele all'Adige
Thomas Skurk
Technical University of Munich
Pedapati S.C. Sri Harsha
University College Dublin
Lieven Van Meulebroek
Ghent university
Lynn Vanhaecke
Ghent university
Rosa Vázquez-Fresno
University of Alberta
David S. Wishart
University of Alberta
Guy Vergeres
Forschungsanstalt Agroscope Changins-Wadenswil
Molecular Nutrition and Food Research
1613-4125 (ISSN)
Vol. 63 1 1800384Subject Categories
Social Sciences Interdisciplinary
Other Humanities not elsewhere specified
Architecture
DOI
10.1002/mnfr.201800384
PubMed
30176196