Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies
Reviewartikel, 2019
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state-of-the-art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful “tips and tricks” along the analytical workflow.
GC–MS
NMR
LC–MS
metabolomics
nutrition
Författare
Marynka M. Ulaszewska
Istituto Agrario San Michele all'Adige
Christoph H. Weinert
Max Rubner-Institut, Germany
Alessia Trimigno
Universita di Bologna
Reto Portmann
Forschungsanstalt Agroscope Changins-Wadenswil
Cristina Andres-Lacueva
Universitat de Barcelona
René Badertscher
Forschungsanstalt Agroscope Changins-Wadenswil
Lorraine Brennan
University College Dublin
Carl Brunius
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Achim Bub
Max Rubner-Institut, Germany
Francesco Capozzi
Universita di Bologna
Marta Cialiè Rosso
Universita degli Studi di Torino
Chiara E. Cordero
Universita degli Studi di Torino
Hannelore Daniel
Technische Universität München
Stéphanie Durand
Université Clermont Auvergne
Bjoern Egert
Max Rubner-Institut, Germany
Paola G. Ferrario
Max Rubner-Institut, Germany
Edith J.M. Feskens
Wageningen University and Research
Pietro Franceschi
Istituto Agrario San Michele all'Adige
Mar Garcia-Aloy
Universitat de Barcelona
Franck Giacomoni
Université Clermont Auvergne
Pieter Giesbertz
Technische Universität München
Raúl González-Domínguez
Universitat de Barcelona
K. Hanhineva
Itä-Suomen Yliopisto
Lieselot Y. Hemeryck
Universiteit Gent
Joachim Kopka
Max-Planck-Gesellschaft
Sabine E. Kulling
Max Rubner-Institut, Germany
Rafael Llorach
Universitat de Barcelona
Claudine Manach
Université Clermont Auvergne
Fulvio Mattivi
Universita degli Studi di Trento
Istituto Agrario San Michele all'Adige
Carole Migné
Université Clermont Auvergne
Linda H. Münger
Forschungsanstalt Agroscope Changins-Wadenswil
Beate Ott
Technische Universität München
Gianfranco Picone
Universita di Bologna
Grégory Pimentel
Forschungsanstalt Agroscope Changins-Wadenswil
E. Pujos-Guillot
Université Clermont Auvergne
Samantha Riccadonna
Istituto Agrario San Michele all'Adige
Manuela J. Rist
Max Rubner-Institut, Germany
Caroline Rombouts
Universiteit Gent
Josep Rubert
Istituto Agrario San Michele all'Adige
Thomas Skurk
Technische Universität München
Pedapati S.C. Sri Harsha
University College Dublin
Lieven Van Meulebroek
Universiteit Gent
Lynn Vanhaecke
Universiteit Gent
Rosa Vázquez-Fresno
University of Alberta
David S. Wishart
University of Alberta
Guy Vergeres
Forschungsanstalt Agroscope Changins-Wadenswil
Molecular Nutrition and Food Research
1613-4125 (ISSN) 1613-4133 (eISSN)
Vol. 63 1 1800384Ämneskategorier
Tvärvetenskapliga studier
Övrig annan humaniora
Arkitektur
DOI
10.1002/mnfr.201800384
PubMed
30176196