A high-performance lab-on-a-chip liquid sensor employing surface acoustic wave resonance: part II
Journal article, 2019

We recently introduced an in-liquid sensing concept based on surface acoustic resonance (SAR) in a lab-on-a-chip resonant device with one electrical port. The 185 MHz one-port SAR sensor has a sensitivity comparable to other surface acoustic wave (SAW) in-liquid sensors, while offering a high quality factor (Q) in water, low impedance, and fairly low susceptibility to viscous damping. In this work, we present significant design and performance enhancements of the original sensor presented in part I. A novel 'lateral energy confinement' (LEC) design is introduced, where the spatially varying reflectivity of the SAW reflectors enables strong SAW localization inside the sensing domain at resonance. An improvement in mass-sensitivity greater than 100% at resonance is achieved, while the measurement noise stays below 0.5 ppm. Sensing performance was evaluated through real-time measurements of the binding of 40 nm neutravidin-coated SiO2nanoparticles to a biotin-labeled lipid bilayer. Two complementary sensing parameters are studied, the shift of resonance frequency and the shift of conductance magnitude at resonance.

resonance

biochemical

sensor

surface acoustic wave

microfluidics

Author

Kiryl Kustanovich

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Ventsislav Yantchev

Astrid Olivefors

Baharan Ali Doosti

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Tatsiana Lobovkina

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Aldo Jesorka

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Journal of Micromechanics and Microengineering

0960-1317 (ISSN)

Vol. 29 2 024001

Reservoir Computing with Real-time Data for future IT (RECORD-IT)

European Commission (Horizon 2020), 2015-09-01 -- 2018-08-31.

Point-of care Influenza Diagnostics FLU-ID

Swedish Foundation for Strategic Research (SSF), 2014-06-01 -- 2019-05-31.

Driving Forces

Innovation and entrepreneurship

Subject Categories

Other Materials Engineering

Other Medical Biotechnology

Nano Technology

Other Electrical Engineering, Electronic Engineering, Information Engineering

Infrastructure

Nanofabrication Laboratory

DOI

10.1088/1361-6439/aaf411

More information

Latest update

7/20/2019