Robustness of Nutrient Signaling Is Maintained by Interconnectivity Between Signal Transduction Pathways
Journal article, 2019

Systems biology approaches provide means to study the interplay between biological processes leading to the mechanistic understanding of the properties of complex biological systems. Here, we developed a vector format rule-based Boolean logic model of the yeast S. cerevisiae cAMP-PKA, Snf1, and the Snf3-Rgt2 pathway to better understand the role of crosstalk on network robustness and function. We identified that phosphatases are the common unknown components of the network and that crosstalk from the cAMP-PKA pathway to other pathways plays a critical role in nutrient sensing events. The model was simulated with known crosstalk combinations and subsequent analysis led to the identification of characteristics and impact of pathway interconnections. Our results revealed that the interconnections between the Snf1 and Snf3-Rgt2 pathway led to increased robustness in these signaling pathways. Overall, our approach contributes to the understanding of the function and importance of crosstalk in nutrient signaling.

Snf3/Rgt2 pathway

crosstalk

logic modeling

nutrient signaling

cAMP-PKA pathway

Boolean logic model

Snf1 pathway

Author

Niek Welkenhuysen

University of Gothenburg

Chalmers, Mathematical Sciences, Applied Mathematics and Statistics

Barbara Maria Schnitzer

University of Gothenburg

Chalmers, Mathematical Sciences, Applied Mathematics and Statistics

Linnea Österberg

University of Gothenburg

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Marija Cvijovic

University of Gothenburg

Chalmers, Mathematical Sciences, Applied Mathematics and Statistics

Frontiers in Physiology

1664-042X (ISSN)

Vol. 9 1964

Subject Categories

Biophysics

Bioinformatics (Computational Biology)

Bioinformatics and Systems Biology

DOI

10.3389/fphys.2018.01964

PubMed

30719010

More information

Latest update

7/2/2019 8