Niek Welkenhuysen

Post doc at Systems and Synthetic Biology

I study how aging factors are retained along cell lineages. Aging of biological cells is characterized by appearance and propagation of harmful molecules which have a deteriorating effect on the cell. Over time accumulation of these aging factors leads to cell death. Aging factors are however not passed on to the offspring of the cell upon cell division. To study the retention of the aging factors I utilize fluorescence microscopy, microfluidic systems and mathematical modelling. The goal of my project is to elucidate the biological process which leads to the mother cell retaining aging factors and prevention of migration of these factors to the daughter cells.


Showing 9 publications


Synergistic effects of repair, resilience and retention of damage determine the conditions for replicative ageing

Johannes Borgqvist, Niek Welkenhuysen, Marija Cvijovic
Scientific Reports. Vol. 10 (1)
Journal article

Robustness of Nutrient Signaling Is Maintained by Interconnectivity Between Signal Transduction Pathways

Niek Welkenhuysen, Barbara Maria Schnitzer, Linnea Österberg et al
Frontiers in Physiology. Vol. 9
Journal article

Creating an automated micromanipulator with a microfluidics and optical tweezers approach to study replicative ageing

Niek Welkenhuysen, Martin Mojica-Benavides, Caroline B. Adiels et al
Optical Manipulation and Its Applications - Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP)
Paper in proceedings

Applying microfluidic systems to study effects of glucose at single-cell level

Niek Welkenhuysen, Caroline B. Adiels, Mattias Goksör et al
Methods in Molecular Biology. Vol. 1713, p. 109-121
Journal article

Single-cell study links metabolism with nutrient signaling and reveals sources of variability

Niek Welkenhuysen, Johannes Borgqvist, M. Backman et al
BMC Systems Biology. Vol. 11 (1), p. Article Number: 59-
Journal article

Time-Resolved Single Cell, Sub-Cellular Compartmentalized Proteomics, Combining Precise Microfluidics, Deconvolution and Ultrasensitive Single-Molecule Microscopy

A. J. M. Wollman, Sviatlana Shashkova, Niek Welkenhuysen et al
Biophysical Journal. Vol. 112 (3), p. 313A-313A
Magazine article

Light-sensing via hydrogen peroxide and a peroxiredoxin

Kristofer Bodvard, K. Peeters, F. Roger et al
Nature Communications. Vol. 8
Journal article

Systems Level Analysis of the Yeast Osmo-Stat

Soheil Rastgou Talemi, Carl Fredrik Tiger, Mikael Andersson et al
Scientific Reports. Vol. 6, p. Article Number: 30950 -
Journal article

Molecular communication: crosstalk between the Snf1 and other signaling pathways

Sviatlana Shashkova, Niek Welkenhuysen, Stefan Hohmann
FEMS Yeast Research. Vol. 15 (4)
Journal article

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