Molecular communication: crosstalk between the Snf1 and other signaling pathways
Journal article, 2015
The yeast Saccharomyces cerevisiae employs different conserved signaling pathways to adapt to altered availability of nutrient and energy sources. Crosstalk between the pathways occurs to integrate different internal and external stimuli and adjust cellular metabolism, growth and proliferation to altered environmental conditions. The main glucose repression pathway, Snf1/Mig1, plays an essential role in adaptation to glucose limitation. However, the Snf1 protein kinase is also involved in regulation of many other cellular processes. We summarize evidence that Snf1 is part of a network of communicating pathways, and we suggest research directions that may help elucidating signal flow within this network.
METHIONINE
Snf1
systems biology
SULFOXIMINE TREATMENT
crosstalk
ENCODING
Biotechnology & Applied Microbiology
Microbiology
GLUCOSE-TRANSPORTER GENE
HAPLOID INVASIVE GROWTH
YEAST SACCHAROMYCES-CEREVISIAE
PAS KINASE
DEPENDENT PROTEIN-KINASE
signaling pathways
ACTIN CYTOSKELETON
CELLULAR INTEGRITY
ACTIVATION-LOOP PHOSPHORYLATION
Mycology
ADENYLATE-CYCLASE
Author
Sviatlana Shashkova
University of Gothenburg
Niek Welkenhuysen
University of Gothenburg
Stefan Hohmann
University of Gothenburg
FEMS Yeast Research
1567-1356 (ISSN) 1567-1364 (eISSN)
Vol. 15 4Subject Categories
Microbiology
DOI
10.1093/femsyr/fov026
PubMed
25994786